Table 4 Univariate Cox regression analysis for B, E, R, T RQ values according to progression free and overall survival
aberrant vs. normal | Progression free survival | Overall survival | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Total N | Events | HR | 95% C.I. | Wald’s p | Total N | Events | HR | 95% C.I. | Wald’s p | ||
Subgroup A | BRCA1 | 51 vs. 100 | 44 vs. 79 | 1.307 | 0.901-1.897 | 0.158 | 51 vs. 102 | 35 vs. 62 | 1.019 | 0.672-1.545 | 0.930 |
ERCC1 | 43 vs. 110 | 36 vs. 88 | 1.224 | 0.829-1.806 | 0.309 | 44 vs. 111 | 30 vs. 68 | 1.169 | 0.760-1.799 | 0.478 | |
RRM1 | 58 vs. 95 | 49 vs. 75 | 1.348 | 0.936-1.939 | 0.108 | 59 vs. 96 | 42 vs. 56 | 1.141 | 0.760-1.715 | 0.524 | |
TYMS | 78 vs. 75 | 63 vs. 61 | 0.849 | 0.593-1.216 | 0.373 | 79 vs. 76 | 50 vs. 48 | 0.871 | 0.583-1.302 | 0.500 | |
Subgroup B | BRCA1 | 58 vs. 113 | 49 vs. 87 | 1.313 | 0.921-1.872 | 0.132 | |||||
ERCC1 | 50 vs. 123 | 41 vs. 96 | 1.251 | 0.867-1.805 | 0.232 | ||||||
RRM1 | 66 vs. 107 | 55 vs. 82 | 1.371 | 0.971-1.935 | 0.073 | ||||||
TYMS | 87 vs. 86 | 68 vs. 69 | 0.922 | 0.656-1.297 | 0.642 | ||||||
Subgroup C | BRCA1 | 62 vs. 123 | 38 vs. 67 | 1.003 | 0.672-1.499 | 0.987 | |||||
ERCC1 | 53 vs. 134 | 32 vs. 74 | 1.02 | 0.672-1.548 | 0.926 | ||||||
RRM1 | 73 vs. 114 | 45 vs. 61 | 1.059 | 0.718-1.562 | 0.772 | ||||||
TYMS | 95 vs. 92 | 56 vs. 50 | 1.027 | 0.699-1.509 | 0.892 | ||||||