Expression of DNA repair and replication genes in non-small cell lung cancer (NSCLC): a role for thymidylate synthetase (TYMS)

Table 3 BRCA1, ERCC1, RRM1 and TYMS mRNA expression in the study sample groups

sample category	BRCA1 mRNA	ERCC1 mRNA	RRM1 mRNA	TYMS mRNA
reference RNA, RQ
Mean	36.71	38.22	42.09	39.70
±SD	0.28	0.10	0.62	0.48
normal lung tissue (N), RQ	40	40	40	40
Mean	35.50	38.23	36.86	33.25
Median	35.66	38.63	37.47	34.10
±SD	2.46	2.93	3.02	2.94
Minimum	22.08	22.08	22.08	25.86
Maximum	39.54	41.78	41.32	37.37
matched NSCLC tissue (T), RQ	35	35	35	35
Mean	36.52	38.45	37.99	36.12
Median	36.98	39.08	38.27	35.57
±SD	2.79	2.95	3.13	1.70
Minimum	23.13	23.13	23.13	32.50
Maximum	40.34	41.13	41.34	38.77
deltaTN^	35	35	35	35
Mean	1.07	0.23	1.13	2.97
Median	1.00	0.31	1.20	2.38
±SD	1.60	1.19	1.37	2.07
Minimum	-1.66	-2.15	-2.24	-0.57
Maximum	4.55	3.38	3.23	10.17
95% C.I.	0.52 - 1.62	-0.18 - 0.64	0.66 - 1.60	-0.03 - 3.92
Sig., 2-tailed (one-sample T-test)	0.0004	0.2610	<0.0001	<0.0001
NSCLC tissue, non-matched, RQ	239	241	241	241
Mean	36.75	38.87	37.59	36.44
Median	37.00	39.12	38.52	36.71
±SD	1.82	1.74	3.99	2.01
Minimum	23.40	27.58	19.54	23.85
Maximum	39.96	41.95	43.02	40.25

Notes to Table 3: ^: relative mRNA expression in matched Tumor (T) vs. Normal (N) tissues followed normal distribution.

ISSN: 1471-2407