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Table 1 Summary of treatment schedules and Antp-p21/chemotherapy combinations

From: Generation of a selectively cytotoxic fusion protein against p53 mutated cancers

Study No Tumour Group Antp-p21 dose Chemotherapy dose PBS Schedule
1 Ovarian (SKOV3) 1 20 mg/kg No No 1 per week for 5 weeks
1 Ovarian (SKOV3) 2   Cis-Pt[2.5 mg/kg]; Taxol [10 mg/kg] No 1 per week for 5 weeks
1 Ovarian (SKOV3) 3 20 mg/kg Cis-Pt[2.5 mg/kg]; Taxol [10 mg/kg] No 1 per week for 5 weeks
1 Ovarian (SKOV3) 4 No No Yes 1 per week for 5 weeks
2 Colon (RKOE6) 1 20 mg/kg No No 1 per week for 5 weeks
2 Colon (RKOE6) 2   5FU [2 mg/kg] LV [1 mg/kg] OxPt [0.2 mg/kg] No 1 per week for 5 weeks
2 Colon (RKOE6) 3 20 mg/kg 5FU [2 mg/kg] LV [1 mg/kg] OxPt [0.2 mg/kg] No 1 per week for 5 weeks
2 Colon (RKOE6) 4 No No Yes 1 per week for 5 weeks
3 Colon (RKOE6) 1 20 mg/kg No No 1 per day (Mon-Fri) for 4 weeks
3 Colon (RKOE6) 2   5FU [2 mg/kg] LV [1 mg/kg] OxPt [0.2 mg/kg] No Chemo M,W F for 4 weeks
3 Colon (RKOE6) 3 20 mg/kg 5FU [2 mg/kg] LV [1 mg/kg] OxPt [0.2 mg/kg] No 1 per day (Mon-Fri) for 4 weeks Chemo M,W F
3 Colon (RKOE6) 4 No No Yes 1 per day (Mon-Fri) for 4 weeks
4 Colon (Colo205) 1 20 mg/kg No No 1 per day (Mon-Fri) for 4 weeks
4 Colon (Colo205) 2   5FU [2 mg/kg] LV [1 mg/kg] OxPt [0.2 mg/kg] No Chemo M,W F for 4 weeks
4 Colon (Colo205) 3 20 mg/kg 5FU [2 mg/kg] LV [1 mg/kg] OxPt [0.2 mg/kg] No 1 per day (Mon-Fri) for 4 weeks Chemo M,W F
4 Colon (Colo205) 4 No No Yes 1 per day (Mon-Fri) for 4 weeks
  1. Treatment studies, doses and schedules.