Table 1 Summary of treatment schedules and Antp-p21/chemotherapy combinations
From: Generation of a selectively cytotoxic fusion protein against p53 mutated cancers
Study No | Tumour | Group | Antp-p21 dose | Chemotherapy dose | PBS | Schedule |
|---|---|---|---|---|---|---|
1 | Ovarian (SKOV3) | 1 | 20 mg/kg | No | No | 1 per week for 5 weeks |
1 | Ovarian (SKOV3) | 2 |  | Cis-Pt[2.5 mg/kg]; Taxol [10 mg/kg] | No | 1 per week for 5 weeks |
1 | Ovarian (SKOV3) | 3 | 20 mg/kg | Cis-Pt[2.5 mg/kg]; Taxol [10 mg/kg] | No | 1 per week for 5 weeks |
1 | Ovarian (SKOV3) | 4 | No | No | Yes | 1 per week for 5 weeks |
2 | Colon (RKOE6) | 1 | 20 mg/kg | No | No | 1 per week for 5 weeks |
2 | Colon (RKOE6) | 2 |  | 5FU [2 mg/kg] LV [1 mg/kg] OxPt [0.2 mg/kg] | No | 1 per week for 5 weeks |
2 | Colon (RKOE6) | 3 | 20 mg/kg | 5FU [2 mg/kg] LV [1 mg/kg] OxPt [0.2 mg/kg] | No | 1 per week for 5 weeks |
2 | Colon (RKOE6) | 4 | No | No | Yes | 1 per week for 5 weeks |
3 | Colon (RKOE6) | 1 | 20 mg/kg | No | No | 1 per day (Mon-Fri) for 4 weeks |
3 | Colon (RKOE6) | 2 |  | 5FU [2 mg/kg] LV [1 mg/kg] OxPt [0.2 mg/kg] | No | Chemo M,W F for 4 weeks |
3 | Colon (RKOE6) | 3 | 20 mg/kg | 5FU [2 mg/kg] LV [1 mg/kg] OxPt [0.2 mg/kg] | No | 1 per day (Mon-Fri) for 4 weeks Chemo M,W F |
3 | Colon (RKOE6) | 4 | No | No | Yes | 1 per day (Mon-Fri) for 4 weeks |
4 | Colon (Colo205) | 1 | 20 mg/kg | No | No | 1 per day (Mon-Fri) for 4 weeks |
4 | Colon (Colo205) | 2 |  | 5FU [2 mg/kg] LV [1 mg/kg] OxPt [0.2 mg/kg] | No | Chemo M,W F for 4 weeks |
4 | Colon (Colo205) | 3 | 20 mg/kg | 5FU [2 mg/kg] LV [1 mg/kg] OxPt [0.2 mg/kg] | No | 1 per day (Mon-Fri) for 4 weeks Chemo M,W F |
4 | Colon (Colo205) | 4 | No | No | Yes | 1 per day (Mon-Fri) for 4 weeks |