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Figure 5 | BMC Cancer

Figure 5

From: Generation of a selectively cytotoxic fusion protein against p53 mutated cancers

Figure 5

Combined therapy experiments (see Table 1 for scheduling). (A-B) Single-agent versus combination treatment in the SKOV-3 ovarian carcinoma model. (A) Tumour growth analyses. A comparison of the means of the growth curves using multiple comparison analysis demonstrated that 20 mg/kg Antp-p21:2.5 mg/kg cisplatin:10 mg/kg taxol treatment group performed better (smaller tumour burden, lowest mean rank) versus all the other treatment groups (taxol, cisplatin, cisplatin/taxol alone) in a statistically significant manner (p = 0.023). The Kruskal-Wallis non-parametric test for multiple comparison analysis demonstrated superiority of the Antp-p21/ cisplatin/taxol treatment group versus all the other treatment groups (p = 0.045). (B) Kaplan-Meier survival plot. Antp-p21/cisplatin/taxol combination treatment demonstrated a statistically significant increased overall survival versus the other treatment groups (p = 0.0204).(C-D) Single-agent versus combination treatment in the RKO E6 colon carcinoma model. (C) Tumour growth analyses. Treatment with 20 mg/kg Antp-p21:2 mg/kg fluorouracil:1 mg/kg leucovorin: 0.2 mg/kg oxaliplatin combination treatment was superior in terms of tumour growth retardation. (D) Kaplan-Meier survival curve. Antp-p21/fluorouracil/oxaliplatin combination treatment was superior in terms of prolonging survival to the other treatment groups (p = 0.044) using log rank test and (p = 0.018) using independent sample t-test. (E-F) Chemotherapy versus combination treatment in the RKO E6 colon carcinoma model with a higher dosage schedule. (E) Tumour growth analyses. The Kruskal-Wallis non-parametric test for multiple comparison analysis demonstrated significant reduction on tumour burden in both the treatment groups versus control (20 mg/kg Antp-p21:2 mg/kg 5-fluorouracil: 1 mg/kg leucovorin: 0.2 mg/kg oxaliplatin-treated group p = 0.008, 5-fluorouracil/leucovorin/oxaliplatin-treated group p = 0.043). (F) Kaplan-Meier survival curve. The Antp-p21/5-fluorouracil/oxaliplatin-treated group was superior to that receiving chemotherapy alone with respect to survival (p = 0.0027). (G-H) Chemotherapy versus combination treatment in the Colo 205 colon carcinoma model. (G) Tumour growth analyses. The growth rates of the tumours in these two animal groups (20 mg/kg Antp-p21:2 mg/kg fluorouracil:1 mg/kg leucovorin: 0.2 mg/kg oxaliplatin) vs the same chemotherapy alone demonstrated no significant difference (p = 0.773). (H) Kaplan-Meier survival curve. The animal group receiving chemotherapy demonstrated a median overall survival of 29.76 days whereas the group receiving both chemotherapy and fusion protein 29.33 days (p = 0.349).

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