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Table 2 Univariate and multivariate Cox regression analysis of overall survival among patients AM-RCC who underwent nephrectomy of any kind (n = 81)

From: C-reactive protein in patients with advanced metastatic renal cell carcinoma: Usefulness in identifying patients most likely to benefit from initial nephrectomy

Parameter Univariate Multivariate
  n P HR 95% CI P HR 95% CI
Age, yr        
<62.0 39   1.00    1.00  
≥62.0 42 0.026 1.87 1.08−3.26 0.177 1.51 0.083−2.76
Sex        
Female 25   1.00    X  
Male 56 0.840 0.94 0.53-1.68    
ECOG PS        
0 44 1.00     1.00  
1 32 0.001 2.54 1.45-4.34 0.012 2.22 1.19-4.16
≥2 5 0.000 7.89 2.56-24.3 0.022 4.18 1.23-14.3
Hb        
≥Lower normal limit 45   1.00    1.00  
<Lower normal limit 36 0.047 1.72 1.01-2.92 0.862 1.06 0.58-1.93
LDH        
≦Normal limit × 1.5 51   1.00    x  
>Normal limit × 1.5 30 0.567 1.17 0.69-2.00    
ALP        
≦Normal limit × 1.5 78   1.00    1.00  
>Normal limit × 1.5 3 0.026 3.92 1.18-13.0 0.510 0.60 0.13-2.76
Corrected Ca, mg/dL        
<10.0 50   1.00    x  
≥10.0 31 0.404 0.79 0.45-138    
Max. tumor diameter, cm        
<8.0 41   1.00    x  
≥8.0 40 0.381 0.78 0.45-1.35    
No. of metastatic organ sites        
0,1 35   1.00     
≥2 46 0.054 1.72 0.99-2.99 0.011 2.33 1.21-4.48
CRP, mg/L        
≦18.0 49   1.00    1.00  
>18.0, <67. 20 0.057 1.86 0.98-3.54 0.036 2.06 1.05-4.05
0 ≥ 67.0 12 0.000 6.66 3.16-14.01 0.001 5.85 2.07-16.56
  1. *X, excluded from the multivariate analysis.
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