Table 8 Analysis of 5 highly-scored modules in each size category, with respect to functional groups and pathways, using MetaCoreTM from GeneGO
From: A systems biology approach to the global analysis of transcription factors in colorectal cancer
Module | Functional groups | Pathway (p-value) |
|---|---|---|
Module Size: 3 | Â | Â |
1. CHK2:p53:E2F1 | Apoptosis and Survival | DNA-damage-induced apoptosis (1.63E-6) |
2. ATR:p53: E2F1 | DNA Damage | ATM/ATR regulation of G1/S checkpoint (5.7 E-8) |
| Â | Apoptosis and Survival | DNA-damage-induced apoptosis (1.63E-6) |
3. APEX1:HIF1A:p53 | Transcription | Role of AKT in hypoxia HIF1 activation (1.63E-9) |
4. IL-22:STAT3:STAT2 | Immune Response | IL-22 signalling pathway (4.51E-6) ( Inflammation ) |
5. IL-9R:STAT1:STAT3 | Immune Response | IL-9 signalling pathway (1.64E-5) |
Module Size: 4 | Â | Â |
1. COX-2:NF-kB:p53: NF-kB-p65 | Immune Response | MIF in innate immunity response (1.48E3) (Inflammation) |
2. TNFA: c-Jun: NF-kB:NF-kB-p65 | Apoptosis and Survival | TNFR1 signalling pathway (2.44E-14) |
3. p53:c-ABL:c-Jun: p73 | Apoptosis and Survival | p53 dependent apoptosis (7.67 E-9) |
4. ETS2:ETS1:c-Jun: c-Myc | Immune Response | ETV3 effect on CFSI promoted macrophage differentiation(1.04E-5) |
5. MAPK11:MEF2C: MEF2A:c-Jun | Immune Response | Function of MEF2 in T lymphocytes (0.0003) |
| Â | Â | TLR-signalling pathways (8.63E-10) (Inflammation) |
Module Size: 5 | Â | Â |
1. BCLX:DAND5:ESR1: c-Jun:SP1 | Development | Prolactin receptor signalling (3.52E-10) |
| Â | DNA Damage | Role of Brca1 and Brca2 in DNA repair (8E-13) |
2. TCF7L2:Lef1:c-Myc: PPARD:NRSF | Development | Wnt signalling pathway (2.45E-11) |