Table 3 Details of systemic chemotherapy

Timing of treatment

Chemotherapy plus targeted agent

n = 11 resections (in 9 patients)

 Neoadjuvant plus adjuvant

7 (64%)

 Neoadjuvant alone

4 (36%)

 Adjuvant alone

0

Chemotherapy alone

n = 38 resections (in 29 patients)

 Neoadjuvant plus adjuvant

15 (39%)

 Neoadjuvant alone

13 (34%)

 Adjuvant alone

10 (26%)

None*

n = 7 resections

Type of systemic treatment

 Targeted agents

n = 11 resections (in 9 patients)

 Bevacizumab

8

 Cetuximab

2

 Sunitinib

1

Chemotherapy alone

n = 38 resections (in 29 patients)

 Oxaliplatin

22

 Irinotecan

6

 Mitomycin

5

 5FU/Cape alone

5

Number of cycles

Median (range)

 Pre-operative

4 (2–12)

 Targeted agents

6 (4–12)

 Chemo alone

4 (2–8)

 Post-operative

5 (2–12)

 Targeted agents

6 (4–12)

 Chemo alone

4 (2–12)

Chemotherapy-related complications

 Pre-operative

9 events (8 patients)

 G3/4 neutropenia

2

 G3/4 Thrombocytopenia

1

 ≥G2 neuropathy

2

 G3/4 diarrhoea

1

 G3/4 Chest pain

2

 G3 VTE (DVT)

1

Post-operative

19 events (14 patients)

 G3/4 neutropenia

4

 G3/4 Thrombocytopenia

1

 ≥G2 neuropathy

3

 G3/4 diarrhoea

3

 G3 fatigue

2

 G3 infection

1

 G3 GI bleed

1

 G3 PPE

1

 G3 stomatitis

1

 G3 nausea

1

 VTE (pulmonary embolism)

1