From: Peri-operative chemotherapy in the management of resectable colorectal cancer pulmonary metastases
Patient characteristics | Patients who received peri-operative chemotherapy | Patients who underwent surgery alone | Total cohort |
---|---|---|---|
Number of patients | 38 | 13 | 51 |
Number of pulmonary resections | 56 | 16 | 72 |
Age median (range) | 61.4 (41–78) | 65 (49–78) | 63 (41–78) |
Male:female | 23:15 | 7:6 | 30:21 |
Site of primary | |||
Colon | 20 | 7 | 27 |
Rectum | 18 | 6 | 24 |
Stage at diagnosis | |||
Stage II | 8 | 6 | 14 |
Stage III | 20 | 4 | 24 |
Stage IV | 11 | 3 | 14 |
Site of metastases | |||
Liver | 2 | 3 | 5 |
Lung | 8 | 0 | 8 |
Lung + Omentum | 1 | 0 | 1 |
Adjuvant chemotherapy for primary CRC | |||
Yes | 24 | 7 | 31 |
With neoadjuvant CRT | 3 | 4 | 7 |
With neoadjuvant chemo + CRT | 3 | 0 | 3 |
With Adjuvant RT | 0 | 1 | 1 |
No | 8 | 1 | 9 |
Site of first metastases | |||
Lung only | 29 | 10 | 39 |
Lung + liver | 2 | 0 | 2 |
Liver only | 5 | 3 | 8 |
Peritoneum | 1 | 0 | 1 |
Nodal (para-aortic) | 1 | 0 | 1 |
CEA pre-treatment* | |||
Recorded | 35 (49 resections) | 10 (12 resections) | 45 (61 resections) |
Not Recorded | 3 (7 resections) | 3 (4 resections) | 6 (11 resections) |
>institutional ULN | 7 (8 resections) | 2 (2 resections) | 9 (10 resections) |
Median CEA (range) | 2 μg/dl (1–1094) | 1.5 μg/dl (<1-10) | 2 μg/dl (<1-1094) |