TY - JOUR AU - Kuhlmann, Jan Dominik AU - Schwarzenbach, Heidi AU - Wimberger, Pauline AU - Poetsch, Micaela AU - Kimmig, Rainer AU - Kasimir-Bauer, Sabine PY - 2012 DA - 2012/07/31 TI - LOH at 6q and 10q in fractionated circulating DNA of ovarian cancer patients is predictive for tumor cell spread and overall survival JO - BMC Cancer SP - 325 VL - 12 IS - 1 AB - We recently showed that LOH proximal to M6P/IGF2R locus (D6S1581) in primary ovarian tumors is predictive for the presence of disseminated tumor cells (DTC) in the bone marrow (BM). For therapy-monitoring, it would be highly desirable to establish a blood-based biomarker. Therefore, we quantified circulating DNA (cirDNA) in sera of 63 ovarian cancer patients before surgery and after chemotherapy, measured incidence of LOH at four cancer-relevant chromosomal loci, correlated LOH with tumor cell spread to the BM and evaluated prognostic significance of LOH. SN - 1471-2407 UR - https://doi.org/10.1186/1471-2407-12-325 DO - 10.1186/1471-2407-12-325 ID - Kuhlmann2012 ER -