Table 4 Subgroup analyses of association between mean global methylation level in leukocyte DNA and endogenous sex hormone level by alcohol drinking status and folate intake
Multivariate-adjusted* | Multivariate-adjusted* | P for interaction | ||||
|---|---|---|---|---|---|---|
β | 95% confidence interval | P value | β | 95% confidence interval | P value | |
Alcohol drinking = Non-drinker | Alcohol drinking = Drinker† | |||||
Estradiol (pg/mL) | ||||||
-0.09 | (-0.57, 0.39) | 0.71 | -0.52 | (-1.37, 0.32) | 0.22 | 0.16 |
Bioavailable estradiol (%) | ||||||
0.49 | (0.01, 0.97) | 0.04 | 0.26 | (-0.60, 1.13) | 0.54 | 0.09 |
Estrone (pg/mL) | ||||||
-0.28 | (-0.77, 0.21) | 0.26 | -0.48 | (-1.29, 0.33) | 0.24 | 0.34 |
Sex hormone binding globulin (nmol/L) | ||||||
-0.11 | (-0.61, 0.38) | 0.65 | 0.03 | (-0.77, 0.83) | 0.95 | 0.26 |
Androstenedione (ng/mL) | ||||||
-0.23 | (-0.74, 0.29) | 0.39 | -0.14 | (-0.99, 0.70) | 0.74 | 0.92 |
Dehydroepiandrosterone sulfate (DHEAS) (ug/dL) | ||||||
0.11 | (-0.41, 0.63) | 0.67 | -0.78 | (-1.56, 0.001) | 0.05 | 0.03 |
Testosterone (ng/mL) | ||||||
-0.24 | (-1.36, 0.88) | 0.67 | -0.20 | (-1.95, 1.54) | 0.81 | 0.44 |
Folate intake = Low‡ | Folate intake = High§ | |||||
Estradiol (pg/mL) | ||||||
-0.05 | (-0.71, 0.61) | 0.88 | -0.38 | (-0.94, 0.18) | 0.18 | 0.79 |
Bioavailable estradiol (%) | ||||||
0.64 | (-0.02, 1.30) | 0.06 | 0.26 | (-0.37, 0.88) | 0.42 | 0.47 |
Estrone (pg/mL) | ||||||
-0.30 | (-0.92, 0.32) | 0.34 | -0.35 | (-0.94, 0.24) | 0.25 | 0.93 |
Sex hormone binding globulin (nmol/L) | ||||||
0.08 | (-0.61, 0.77) | 0.82 | -0.12 | (-0.73, 0.48) | 0.69 | 0.74 |
Androstenedione (ng/mL) | ||||||
-0.67 | (-1.36, 0.02) | 0.06 | -0.04 | (-0.60, 0.51) | 0.88 | 0.07 |
Dehydroepiandrosterone sulfate (DHEAS) (ug/dL) | ||||||
-0.45 | (-1.07, 0.17) | 0.15 | -0.12 | (-0.69, 0.46) | 0.68 | 0.42 |
Testosterone (ng/mL) | ||||||
-0.82 | (-2.30, 0.65) | 0.27 | 0.45 | (-0.86, 1.76) | 0.49 | 0.08 |