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Table 3 Mean global methylation level in leukocyte DNA by endogenous sex hormone level

From: Association of postmenopausal endogenous sex hormones with global methylation level of leukocyte DNA among Japanese women

 

Median

No. of subjects

Crude

Multivariate-adjusted*

Mean (%)

Mean (%)

95% confidence interval

β

95% confidence interval

P value

Estradiol (pg/mL)

Lowest

6.8

45

70.3

71.0

(68.9, 73.1)

   

Second

8.2

45

70.8

71.5

(69.5, 73.4)

   

Third

9.7

47

70.6

71.2

(69.3, 73.1)

   

Highest

11.4

48

69.4

70.2

(68.2, 72.1)

   

Continuous (per quartile category)

-0.27

(-0.68, 0.15)

0.20

Bioavailable estradiol (%)

Lowest

16.6

45

69.5

69.7

(67.6, 71.8)

   

Second

20.6

47

70.7

71.2

(69.3, 73.0)

   

Third

26.0

44

70.5

70.8

(68.8, 72.9)

   

Highest

32.5

49

70.4

71.2

(69.2, 73.2)

   

Continuous (per quartile category)

0.41

(-0.01, 0.84)

0.06

Estrone (pg/mL)

Lowest

15.0

38

70.6

71.6

(69.6, 73.7)

   

Second

21.0

54

70.6

71.8

(69.8, 73.7)

   

Third

25.5

40

70.8

71.8

(69.8, 73.9)

   

Highest

31.0

53

69.3

70.4

(68.6, 72.3)

   

Continuous (per quartile category)

-0.39

(-0.80, 0.02)

0.06

Sex hormone binding globulin (nmol/L)

Lowest

44.1

46

69.9

70.9

(68.9, 72.8)

   

Second

67.1

46

70.5

71.6

(69.6, 73.6)

   

Third

84.9

45

70.8

71.7

(69.7, 73.7)

   

Highest

113.5

48

69.9

70.7

(68.8, 72.6)

   

Continuous (per quartile category)

-0.05

(-0.47, 0.37)

0.81

Androstenedione (ng/mL)

Lowest

0.30

39

70.5

71.6

(69.5, 73.6)

   

Second

0.60

44

70.1

71.2

(69.2, 73.1)

   

Third

0.80

55

70.9

71.9

(69.9, 73.9)

   

Highest

1.10

47

69.5

70.5

(68.7, 72.4)

   

Continuous (per quartile category)

-0.24

(-0.67, 0.19)

0.27

Dehydroepiandrosterone sulfate (DHEAS) (ug/dL)

Lowest

27.5

46

70.7

71.8

(69.7, 73.8)

   

Second

45.0

45

69.8

70.7

(68.8, 72.7)

   

Third

63.0

47

70.7

71.4

(69.5, 73.3)

   

Highest

95.0

47

69.9

70.8

(68.8, 72.8)

   

Continuous (per quartile category)

-0.24

(-0.66, 0.18)

0.26

Testosterone (ng/mL)

Lowest

0.00

90

70.4

71.1

(69.3, 73.0)

   

Highest

0.11

95

70.1

71.0

(69.1, 72.8)

   

Continuous (per median category)

-0.17

(-1.10, 0.77)

0.73

  1. * Adjusted for age (continuous), family history of breast cancer (yes, no), history of benign breast disease (yes, no), age at menarche (continuous), age at menopause (continuous), number of births (0, 1, 2-3, 4+), age at first birth (≤24, 25-26, ≥27, nulliparous), height (continuous), body mass index (continuous), smoking (never smokers, ever smokers), alcohol drinking (non-drinkers, occasional drinkers, regular drinkers), physical activity in past 5 years (no, ≤2 days/week, ≥3 days/week), and energy-adjusted folate intake (continuous).
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BMC Cancer

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