Validation and prognostic significance of the genome-wide expression signatures in RCC. A. Linear discriminant analysis of groups “A”, “B” and “C” with 4 selected variables (genes). Classification of the three groups using the 4 highest ranked variables of Random Forest allows linear discriminant analysis (LDA) with 96.94% accuracy. B. Kaplan–Meier analysis of tumor-specific survival in 176 RCC patients. Subgroup A (high MVD, DEK and MSH positive), B (high or low MVD, MSH6 negative) and C (low MVD, DEK and MSH positive) (log rank test: p < 0.0001).