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Table 3 Factors associated with LN evaluation (LNE) or use of adjuvant chemotherapy (ACT) in colon cancer practices: uni- and multi-variate models

From: Quality indicators for colorectal cancer surgery and care according to patient-, tumor-, and hospital-related factors

  Univariate Multivariate
  OR [95%CI] p OR [95%CI] p
Evaluation of ≥ 12 LNs* 581 pts 399 pts
ECOG score    0.011    0.014
0 1 ref   1 ref  
1 2.02 [1.20-3.41]   2.10 [1.17-3.76]  
2 and more 0.81 [0.41-1.60]   0.72 [0.33-1.55]  
Tumor location    0.003    0.036
Right 1 ref   1   
Left 0.54 [0.36-0.81]   0.58 [0.34-0.97]  
Post-operative stage    0.525    0.044
I -II 1 ref   1 ref  
III 1.14 [0.76-1.72]   1.73 [1.01-2.95]  
Hospital surgery volume    0.001    <0.001
< 30 operations 1 ref   1 ref  
≥ 30 operations 2.48 [1.46-4.21]   3.34 [1.70-6.56]  
Surgical district    <0.001    0.006
1 1 ref   1.00 ref  
2 1.62 [0.90-2.91]   2.07 [0.97-4.42]  
3 1.10 [0.48-2.51]   1.30 [0.35-4.88]  
4 0.34 [0.18-0.64]   0.38 [0.17-0.85]  
5 1.32 [0.73-2.40]   1.54 [0.84-3.40]  
Receiving ACT among stage II† 258 pts    255 pts   
Age (years)    <0.001    <0.0011
≥75 1 ref   1 ref  
< 75 8.68 [4.06-18.54]   28.49 [8.41-96.53]  
Local extension    <0.001    <0.001
pT3 1 ref   1 ref  
pT4 4.07 [2.12-7.81]   12.30 [3.81-39.75]  
Surgery context    <0.001    <0.001
Scheduled 1 ref   1 ref  
Emergency 6.89 [3.21-14.73]   25.31 [6.79-94.34]  
Hospital of surgery    0.009    0.020
Public 1 ref   1 ref  
Private 2.18 [1.21-3.95]   2.61 [1.16-5.87]  
Surgical district    0.090    0.036
1 1 ref   1 ref  
2 0.53 [0.25-1.13]   0.54 [0.19-1.53]  
3 1.89 [0.54-6.56]   1.45 [0.31-6.75]  
4 0.28 [0.06-1.29]   0.06 [0.08-0.39]  
5 0.57 [0.25-1.29]   0.44 [0.14-1.44]  
Not receiving ACT among stage III† 231 pts    226 pts   
Age (years)    <0.001    <0.001
< 75 1 ref   1 ref  
≥75 8.80 [4.51-17.17]   8.83 [4.34-17.95]  
Comorbid conditions    0.001    0.010
None 1 ref   1 ref  
One or more 3.46 [1.65-7.27]   3.04 [1.31-7.04]  
Hospitals    0.024    0.285
Private 1 ref   1 ref  
Public 1.94 [1.09-3.45]   1.48 [0.72-3.03]  
  1. * Logistic model was adjusted by gender and age. Factors entered into the model but not retained are: department of patient residence, pre-operative colonoscopy, pre-operative abdominal ultrasound, usN, grade, type of colectomy. ACT stage II and III: Logistic model was adjusted by gender and grade. Factors entered into the model but not retained for stage II patients: department of patient residence, comorbidities, family history of colorectal cancer; for stage III: family history of colorectal cancer and surgical district.