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Table 1 Selected genes in the intrinsic apoptotic pathway

From: Identification of BIRC6 as a novel intervention target for neuroblastoma therapy

Gene family or category Gene (alias)
Anti-apoptotic members of BCL2 family BCL2
  MCL1
  BCL2L1 (BCLXL)
  BCL2L2 (BCLW)
  BCL2A1
  BCL2L10
Pro-apoptotic members of BCL2 family BBC3 (PUMA)
  BCL2L11 (BIM)
  BID
  PMAIP1 (NOXA)
  BAD
  BIK
  HRK
  BCL2L14
  BMF
Mitochondrial permeabilization BAX
  BAK1
Cytoplasmic pro-apoptotic genes DIABLO
  CYCS
  APAF1
Caspases, activated by mitochondrial apoptotic pathway CASP3
  CASP6
  CASP7
  CASP9
IAPs NAIP
  XIAP
  BIRC5
  BIRC6
  BIRC7
Activation of mitochondrial apoptotic pathway TP53
  CASP2