Table 1 Selected genes in the intrinsic apoptotic pathway
From: Identification of BIRC6 as a novel intervention target for neuroblastoma therapy
Gene family or category | Gene (alias) |
|---|---|
Anti-apoptotic members of BCL2 family | BCL2 |
MCL1 | |
BCL2L1 (BCLXL) | |
BCL2L2 (BCLW) | |
BCL2A1 | |
BCL2L10 | |
Pro-apoptotic members of BCL2 family | BBC3 (PUMA) |
BCL2L11 (BIM) | |
BID | |
PMAIP1 (NOXA) | |
BAD | |
BIK | |
HRK | |
BCL2L14 | |
BMF | |
Mitochondrial permeabilization | BAX |
BAK1 | |
Cytoplasmic pro-apoptotic genes | DIABLO |
CYCS | |
APAF1 | |
Caspases, activated by mitochondrial apoptotic pathway | CASP3 |
CASP6 | |
CASP7 | |
CASP9 | |
IAPs | NAIP |
XIAP | |
BIRC5 | |
BIRC6 | |
BIRC7 | |
Activation of mitochondrial apoptotic pathway | TP53 |
CASP2 |