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Figure 5 | BMC Cancer

Figure 5

From: Longitudinal MRI contrast enhanced monitoring of early tumour development with manganese chloride (MnCl2) and superparamagnetic iron oxide nanoparticles (SPIOs) in a CT1258 based in vivo model of prostate cancer

Figure 5

T1 weighted MRI scan, three dimensional reconstruction and histological analyses of a tumour induced by injection of MnCl 2 labelled CT1258 cells into a male NOD-scid mouse. A: RARE T1 weighted in vivo MRI scan 24 days after sc injection of the labelled cells. On the right abdominal flank, a tumour mass developed. No signs of metastasis were detected. B: Three dimensional graphical analysis of the tumour structure 24 days after injection of the labelled cells. C and D: Histological analysis of the obtained tumour mass. The obtained tumour showed the characteristic appearance and morphology of a prostate adenocarcinoma. The analysis displayed pleomorphic cells with a high mitotic index. The centre of the obtained tumour was highly necrotic and the tumour infiltrated into the subcutaneous fat tissue. The tumour developed an incomplete fibrous capsule. White arrow: localisation of the developed tumour at the site of injection.

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