TG2 mediated activation of NF-κB and Akt are interconnected. Left panel: Representative immunoblots showing phosphorylation levels of Akt in MEFtg2-/- and breast cancer cells overexpression TG2 and m-TG2 under the same experimental conditions as shown in Figure 1. Akt immunoblots are shown as controls. Right panel: Histograms showing quantitative difference in Akt phosphorylation as shown in the left panel. Data are represented as mean ± SEM, n = 4. * P < 0.05 (TG2 vs. vector control); # P < 0.05 (m-TG2 vs. TG2); @ P < 0.05 (m-TG2 vs. vector control).