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Table 4 Joint effect of serum estradiol level and ESR2 genotypes on colorectal cancer risk in men

From: Association of estrogen receptor betavariants and serum levels of estradiol with risk of colorectal cancer: a case control study

   Controls (n = 378) Cases (n = 359)   
Variables   n % n % ORa (95% CI) ORb (95% CI)
Estradiol + rs1256049       
Low CT/TT 127 33.8 96 27.3 1.0 1.0
  CC 80 21.3 87 24.7 1.6 (1.0–2.4) 1.7 (1.1–2.6)
High CT/TT 109 29.0 101 28.7 1.5 (1.0–2.3) 1.2 (0.8–1.9)
  CC 60 16.0 68 19.3 1.6 (1.0–2.5) 1.4 (0.8–2.3)
Estradiol + rs4986938       
Low CC 162 43.4 144 40.6 1.0 1.0
  CT/TT 42 11.3 43 12.1 1.1 (0.7–1.9) 1.1 (0.6–1.9)
High CC 136 36.5 113 31.8 1.0 (0.7–1.4) 0.8 (0.6–1.2)
  CT/TT 33 8.9 55 15.5 2.3 (1.4–3.9) 1.6 (0.9–2.9)
  1. aORs were calculated using unconditional logistic regression model adjusted for age.
  2. bORs were calculated using unconditional logistic regression model adjusted for age, smoking status and alcohol drinking status.