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Table 4 Joint effect of serum estradiol level and ESR2 genotypes on colorectal cancer risk in men

From: Association of estrogen receptor betavariants and serum levels of estradiol with risk of colorectal cancer: a case control study

  

Controls (n = 378)

Cases (n = 359)

  

Variables

 

n

%

n

%

ORa (95% CI)

ORb (95% CI)

Estradiol + rs1256049

      

Low

CT/TT

127

33.8

96

27.3

1.0

1.0

 

CC

80

21.3

87

24.7

1.6 (1.0–2.4)

1.7 (1.1–2.6)

High

CT/TT

109

29.0

101

28.7

1.5 (1.0–2.3)

1.2 (0.8–1.9)

 

CC

60

16.0

68

19.3

1.6 (1.0–2.5)

1.4 (0.8–2.3)

Estradiol + rs4986938

      

Low

CC

162

43.4

144

40.6

1.0

1.0

 

CT/TT

42

11.3

43

12.1

1.1 (0.7–1.9)

1.1 (0.6–1.9)

High

CC

136

36.5

113

31.8

1.0 (0.7–1.4)

0.8 (0.6–1.2)

 

CT/TT

33

8.9

55

15.5

2.3 (1.4–3.9)

1.6 (0.9–2.9)

  1. aORs were calculated using unconditional logistic regression model adjusted for age.
  2. bORs were calculated using unconditional logistic regression model adjusted for age, smoking status and alcohol drinking status.