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Table 2 ESR2 genotype frequencies in colorectal cancer cases and controls and odds ratio estimates

From: Association of estrogen receptor betavariants and serum levels of estradiol with risk of colorectal cancer: a case control study

 

Controlsa (n = 445)

Cases (n = 390)

  

Genotypes

n

%

n

%

ORb (95% CI)

P-valueb

rs1256049

      

 CC (Ref.c)

167

37.9

168

43.9

1.0

0.029

 CT/TT

274

62.1

215

56.1

0.7 (0.5–1.0)

 

rs4986938

      

 CC (Ref.c)

349

79.9

277

71.8

1.0

0.036

 CT/TT

88

20.1

109

28.2

1.5 (1.0–2.1)

 

rs1256049 + rs4986938

     

 0 risk genotype (Ref.c)

232

53.2

165

43.4

1.0

0.014

 1 risk genotype

156

35.8

154

40.5

1.3 (0.9–1.8)

 

 2 risk genotypes

48

11.0

61

16.1

2.0 (1.3–3.3)

 
     

P trend =

0.003

 No risk genotype (Ref.c)

232

53.2

165

43.4

1.0

0.016

 With risk genotype

204

46.8

215

56.6

1.5 (1.1–2.0)

 
  1. a The genotype frequencies in controls were in Hardy-Weinberg equilibrium (P = 0.686 for rs1256049 and P = 0.669 for rs4986938, Chi-square test).
  2. bORs and P values were calculated using unconditional logistic regression model adjusted for age, smoking status and alcohol drinking status.
  3. cRef. = reference group.
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BMC Cancer

ISSN: 1471-2407

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