| |
Controlsa (n = 445)
|
Cases (n = 390)
| | |
|---|
|
Genotypes
|
n
|
%
|
n
|
%
|
ORb (95% CI)
|
P-valueb
|
|---|
|
rs1256049
| | | | | | |
|
CC (Ref.c)
|
167
|
37.9
|
168
|
43.9
|
1.0
|
0.029
|
|
CT/TT
|
274
|
62.1
|
215
|
56.1
|
0.7 (0.5–1.0)
| |
|
rs4986938
| | | | | | |
|
CC (Ref.c)
|
349
|
79.9
|
277
|
71.8
|
1.0
|
0.036
|
|
CT/TT
|
88
|
20.1
|
109
|
28.2
|
1.5 (1.0–2.1)
| |
|
rs1256049 + rs4986938
| | | | | |
|
0 risk genotype (Ref.c)
|
232
|
53.2
|
165
|
43.4
|
1.0
|
0.014
|
|
1 risk genotype
|
156
|
35.8
|
154
|
40.5
|
1.3 (0.9–1.8)
| |
|
2 risk genotypes
|
48
|
11.0
|
61
|
16.1
|
2.0 (1.3–3.3)
| |
| | | | | |
P
trend
=
|
0.003
|
|
No risk genotype (Ref.c)
|
232
|
53.2
|
165
|
43.4
|
1.0
|
0.016
|
|
With risk genotype
|
204
|
46.8
|
215
|
56.6
|
1.5 (1.1–2.0)
| |
-
a The genotype frequencies in controls were in Hardy-Weinberg equilibrium (P = 0.686 for rs1256049 and P = 0.669 for rs4986938, Chi-square test).
-
bORs and P values were calculated using unconditional logistic regression model adjusted for age, smoking status and alcohol drinking status.
-
cRef. = reference group.
