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Table 2 ESR2 genotype frequencies in colorectal cancer cases and controls and odds ratio estimates

From: Association of estrogen receptor betavariants and serum levels of estradiol with risk of colorectal cancer: a case control study

  Controlsa (n = 445) Cases (n = 390)   
Genotypes n % n % ORb (95% CI) P-valueb
rs1256049       
 CC (Ref.c) 167 37.9 168 43.9 1.0 0.029
 CT/TT 274 62.1 215 56.1 0.7 (0.5–1.0)  
rs4986938       
 CC (Ref.c) 349 79.9 277 71.8 1.0 0.036
 CT/TT 88 20.1 109 28.2 1.5 (1.0–2.1)  
rs1256049 + rs4986938      
 0 risk genotype (Ref.c) 232 53.2 165 43.4 1.0 0.014
 1 risk genotype 156 35.8 154 40.5 1.3 (0.9–1.8)  
 2 risk genotypes 48 11.0 61 16.1 2.0 (1.3–3.3)  
      P trend = 0.003
 No risk genotype (Ref.c) 232 53.2 165 43.4 1.0 0.016
 With risk genotype 204 46.8 215 56.6 1.5 (1.1–2.0)  
  1. a The genotype frequencies in controls were in Hardy-Weinberg equilibrium (P = 0.686 for rs1256049 and P = 0.669 for rs4986938, Chi-square test).
  2. bORs and P values were calculated using unconditional logistic regression model adjusted for age, smoking status and alcohol drinking status.
  3. cRef. = reference group.