Table 3 Correlation between fatal PH and pathological characteristics
No. of patients (%) | P value† | |||
|---|---|---|---|---|
Characteristics | Non-fatal PH | Fatal PH | ||
Overall number | 571 | 12 (2.1) | ||
Age (y) | median (range) | 65 (31-85) | ||
≤ 70 | 437 (76.5) | 12 (100) | 0.078 | |
> 70 | 134 (23.5) | 0 (0) | ||
Gender | ||||
Male | 472 (82.7) | 10 (83.3) | 1.000 | |
Female | 99 (17.3) | 2 (16.7) | ||
ECOG PS | ||||
0 | 170 (29.8) | 1 (8.3) | 0.196 | |
1, 2 | 401 (70.2) | 11 (91.7) | ||
Smoking history | ||||
Non smoker | 51 (8.9) | 0 (0) | 0.613 | |
Ever-smoker | 520 (91.1) | 12 (100) | ||
Histology | ||||
Squamous cell carcinoma | 198 (34.7) | 10 (83.3) | < 0.001* | |
Nonsquamous NSCLC | 373 (65.3) | 2 (16.7) | ||
TNM stage | ||||
II | 30 (5.3) | 0 (0) | 1.000 | |
III | 541 (94.7) | 12 (100) | ||
Tumor laterality | ||||
Right | 341 (59.7) | 5 (41.7) | 0.242 | |
Left | 230 (40.3) | 7 (58.3) | ||
Tumor location | ||||
Central | 121 (21.2) | 6 (50.0) | 0.028* | |
Peripheral | 450 (78.8) | 6 (50.0) | ||
Major cavitation | ||||
Absent | 560 (98.1) | 9 (75.0) | < 0.001* | |
Present | 11 (1.9) | 3 (25.0) | ||
Baseline cough | ||||
Absent | 313 (54.8) | 4 (33.3) | 0.155 | |
Present | 258 (45.2) | 8 (66.7) | ||
Baseline chest pain | ||||
Absent | 475 (83.2) | 9 (75.0) | 0.438 | |
Present | 96 (16.8) | 3 (25.0) | ||
Baseline hemoptysis | ||||
Absent | 458 (80.2) | 10 (83.3) | 1.000 | |
Present | 113 (19.8) | 2 (16.7) | ||