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Table 2 Univariate and multivariate Cox analyses of prognosis

From: Circulating endothelial cells and other angiogenesis factors in pancreatic carcinoma patients receiving gemcitabine chemotherapy

Univariate analysis HR 95% CI P
Age: Over 70 vs. Below 70 0.52 0.25–1.13 0.1
Sex: Male vs. Female 1.00 0.48–2.08 0.99
Stage: IV + Recurrence vs. III 2.21 1.03–4.71 0.04
ECOG PS: 2 + 1 vs. 0 2.72 1.29–5.70 0.008
Pancreatic tumor location: Head vs. Others 0.94 0.46–1.90 0.86
CA19-9 (cut-off: 10,000 U/mL): CA19-9high vs. CA19-9low 1.77 0.75–4.15 0.19
CRP level (cut-off: 1.0 mg/dL): CRPhigh vs. CRPlow 2.49 1.14–5.42 0.02
Histology: Poorly differentiated vs. Others 1.09 0.52–2.27 0.82
Second line therapy: Yes vs. No 0.61 0.30–1.24 0.17
CEC level (cut-off: 166 cells/4 mL): CEChigh vs. CEClow 5.18 2.23–12.03 <0.001
IL-6 (cut-off: 19.3 pg/mL): IL-6high vs. IL-6low 2.52 0.73–8.64 0.14
IL-8 (cut-off: 11.3 pg/mL): IL-8high vs. IL-8low 1.74 0.82–3.67 0.15
IL-10 (cut-off: 7.82 pg/mL): IL-10high vs. IL-10low 5.05 1.55–16.39 0.007
VEGF (cut-off: 44.1 pg/mL): VEGFhigh vs. VEGFlow 1.22 0.60–2.47 0.59
PDGF-BB (cut-off: 1127.5 pg/mL): PDGF-BBhigh vs. PDGF-BBlow 0.93 0.43–2.04 0.86
HGF (cut-off: 471.3 pg/mL): HGFhigh vs. HGFlow 2.52 1.22–5.21 0.01
SDF-1 alpha (cut-off: 110.6 pg/mL): SDF-1 alphahigh vs. SDF-1 alphalow 1.23 0.60–2.53 0.56
Multivariate analysis HR 95% CI P
Stage: IV + Recurrence vs. III 2.04 0.78–5.35 0.15
ECOG PS: 2 + 1 vs. 0 2.58 0.98–6.76 >0.05
CRP level (cut-off: 1.0 mg/dL): CRPhigh vs. CRPlow 2.04 0.62–6.76 0.24
CEC level (cut-off: 166 cells/4 mL): CEChigh vs. CEClow 5.14 1.83–14.45 0.002
IL-10 (cut-off: 7.82 pg/mL): IL-10high vs. IL-10low 5.26 1.26–22.22 0.02
HGF (cut-off: 471.3 pg/mL): HGFhigh vs. HGFlow 1.34 0.46–3.91 0.59
  1. Abbreviations: HR = hazard ratio; CI = confidence interval; ECOG PS = Eastern Cooperative Oncology Group performance status; CEC = circulating endothelial cells; IL = interleukin; PDGF-BB = platelet-derived growth factor-B chain; VEGF = vascular endothelial growth factor; HGF = hepatocyte growth factor; CA19-9 = carbohydrate antigen 19–9; CRP = C-reactive protein; CEA = carcinoembryonic antigen.