Correlation of hornerin expression with breast cancer subtype and TNM staging. (A) Representative images of breast cancer biopsies that were subjected to immunohistochemical analysis using a hornerin-specific antibody or corresponding negative control (219 individual patient samples analyzed). Yellow bar = 200 μM. Hornerin expression in correlation with (B) breast cancer subtype IDC = invasive ductal carcinoma. ILC = invasive lobular carcinoma, (C) tumor grade, and (D) lymph node metastasis. Data represent mean relative intensity +/− SD. *P < 0.05.