Table 5 The relationship between the IGF-1R, IGF2R, ERα and ERβ protein expression and clinico-pathological features of endometrioid adenocarcinoma
Clinical pathology | n | ERα | ERβ | IGF-1R | IGF-2R | |||||
|---|---|---|---|---|---|---|---|---|---|---|
Positive (%) | Strong positive(%) | Positive (%) | Strong positive(%) | Positive (%) | Strong positive(%) | Positive (%) | Strong positive(%) | |||
Surgico-pathological stage | I | 45 | 40(88.9) | 19(42.2) | 45(100) | 43(95.6) | 39(86.7) | 7(15.6) | 11(24.4) | 5(11.1) |
II | 19 | 14(73.7) | 0(0) | 18(94.7) | 13(68.4) | 17(89.5) | 10(52.6) | 2(10.5) | 0(0) | |
III | 16 | 5(31.3) | 0(0) | 15(93.8) | 16(100) | 16(100) | 15(93.8) | 2(12.5) | 0(0) | |
x 2 | 18.935 | 7.334 | 3.388 | 3.225 | 3.886 | 31.727 | 2.316 | 2.544 | ||
P value | 0.000 | 0.013 | 0.184 | 0.237 | 0.143 | 0.000 | 0.314 | 0.291 | ||
Histological grade | G1 | 21 | 21(100) | 9(42.8) | 21(100) | 21(100) | 13(61.9) | 4(19.1) | 10(47.6) | 5(23.8) |
G2 | 45 | 33(73.3) | 10(22.2) | 45(100) | 38(84.4) | 45(100) | 15(33.3) | 4(19.1) | 0(0) | |
G3 | 14 | 5(35.7) | 0(0) | 13(92.9) | 13(92.9) | 14(100) | 13(92.9) | 1(7.1) | 0(0) | |
x 2 | 21.663 | 2.543 | 3.547 | 3.844 | 24.103 | 20.972 | 13.974 | 2.689 | ||
P value | 0.000 | 0.447 | 0.170 | 0.163 | 0.000 | 0.000 | 0.001 | 0.304 | ||
Depth of myometrial invasion | ≤1/2 | 58 | 53(91.4) | 13(22.47) | 56(96.6) | 51(87.9) | 50(86.2) | 14(24.1) | 11(19.0) | 5(8.6) |
>1/2 | 22 | 6(27.3) | 6(27.3) | 22(100) | 21(95.5) | 22(100) | 18(81.8) | 4(18.2) | 0(0) | |
x 2 | 33.853 | 3.345 | 0.006 | 0.102 | 2.013 | 22.111 | 0.000 | 1.015 | ||
P value | 0.000 | 0.264 | 0.936 | 0.845 | 0.156 | 0.000 | 1.000 | 0.933 | ||