|
Parameter
| |
Cluster-1 (n = 35)
|
Cluster-2 (n = 12)
|
Cluster-3 (n = 22)
|
Cluster-4 (n = 14)
|
p-global
|
|
Microsatellite instability
|
MSS
|
33
|
11
|
21
|
9
|
0.039LR,a
|
| |
MSI
|
2
|
1
|
1
|
5
| |
|
Histologic subtypes
|
Conventional
|
34
|
12
|
21
|
8
|
0.001LR,b
|
| |
Mucinous
|
1
|
0
|
1
|
6
| |
|
% Stroma content frozen sample
|
Mean
|
11.2
|
18.8
|
23.4
|
18.9
|
<0.001KW,c
|
| |
SD
|
6.0
|
10.3
|
10.5
|
14.8
| |
|
% Stroma Paraffin
|
Mean
|
12.6
|
17.1
|
18.9
|
16.8
|
0.047KW,d
|
| |
SD
|
6.0
|
9.9
|
8.6
|
14.2
| |
|
nuclear β-Catenin (IHC)
|
LOW
|
21
|
9
|
11
|
12
|
0.021LR,e
|
| |
MEDIUM
|
4
|
0
|
6
|
1
| |
| |
HIGH
|
10
|
2
|
5
|
0
| |
|
BRAF mutations (V600E)
|
Mutated
|
0
|
1
|
1
|
6
|
<0.001LR,f
|
| |
WT
|
35
|
11
|
21
|
8
| |
|
Dukes Stage
|
A
|
9
|
5
|
4
|
4
|
0.646LR
|
| |
B
|
9
|
3
|
6
|
7
| |
| |
C
|
8
|
2
|
6
|
2
| |
| |
D
|
9
|
2
|
6
|
1
| |
- LR: Likelihood Ratio. KW: Kruskal Wallis. Pair wise comparisons: a:C4 ≠ C1 (0.015); C4 ≠ C3(0.024); b: C4 ≠ C1 (0.001);C2 ≠ C4 (0.017); C4 ≠ C3(0.008); c: C1 ≠ C4 (0.013);C1 ≠ C2 (0.020); C1 ≠ C3 (<0.001); d: C1 ≠ C3 (0.005); e:C1 ≠ C4 (0.020); C2 ≠ C3(0.047); C3 ≠ C4 (0.014); f:C4 ≠ C1 (<0.001); C4 ≠ C2(<0.081); C4 ≠ C3 (0.008); Frozen stroma vsparaffin ICC of 0.781 (IC95% 0.681-0.852)p < 0.001.
