Table 3 Correlation of tumor subgroups with clinical parameters

Parameter

Cluster-1 (n = 35)

Cluster-2 (n = 12)

Cluster-3 (n = 22)

Cluster-4 (n = 14)

p-global

Microsatellite instability

MSS

33

11

21

9

0.039^LR,a

MSI

2

1

1

5

Histologic subtypes

Conventional

34

12

21

8

0.001^LR,b

Mucinous

1

0

1

6

% Stroma content frozen sample

Mean

11.2

18.8

23.4

18.9

<0.001^KW,c

SD

6.0

10.3

10.5

14.8

% Stroma Paraffin

Mean

12.6

17.1

18.9

16.8

0.047^KW,d

SD

6.0

9.9

8.6

14.2

nuclear β-Catenin (IHC)

LOW

21

9

11

12

0.021^LR,e

MEDIUM

4

0

6

1

HIGH

10

2

5

0

BRAF mutations (V600E)

Mutated

0

1

1

6

<0.001^LR,f

WT

35

11

21

8

Dukes Stage

A

9

5

4

4

0.646^LR

B

9

3

6

7

C

8

2

6

2

D

9

2

6

1