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Table 4 Correlation of Cyclin A1 expression in immunohistochemistry with clinicopathological characteristics in HNSCC

From: Cyclin A1 shows age-related expression in benign tonsils, HPV16-dependent overexpression in HNSCC and predicts lower recurrence rate in HNSCC independently of HPV16

Clinicopathological parameter

N

Performed Statistic

Subgroups

P

Age [y]

81

Spearman Rank Order

σ = −0.070

0.532

Sex

81

Mann–Whitney Rank Sum

male vs. female

0.964

Primary site

    

Tonsil

33

Fisher exact

CCNA1 <4 vs. ≥4

0.623

Base of the tongue

28

Fisher exact

CCNA1 <4 vs. ≥4

0.447

Anterior two-thirds of the tongue

9

Fisher exact

CCNA1 <4 vs. ≥4

0.268

Floor of the mouth

2

Fisher exact

CCNA1 <4 vs. ≥4

1.000

Hypopharynx

1

Fisher exact

CCNA1 <4 vs. ≥4

1.000

Soft palate

2

Fisher exact

CCNA1 <4 vs. ≥4

1.000

Supraglottic

3

Fisher exact

CCNA1 <4 vs. ≥4

0.551

Unknown (CUP)

3

Fisher exact

CCNA1 <4 vs. ≥4

0.208

T

72

Fisher exact

T1/2 vs. T3/4

0.591

N

73

Fisher exact

N0/1 vs. N2/3

0.312

M

75

Fisher exact

M0 vs. M1

0.094

G

62

Fisher exact

G1/2 vs. G3/4

0.404

UICC stage

71

Fisher exact

stage1/2 vs. stage3/4

1.000

Recurrence rate

64

Mann–Whitney Rank Sum

Recurrence vs. no recurrence

univariate

0.002

multivariate

0.013

Secondary tumor

78

Mann–Whitney Rank Sum

sec. tumor vs no sec. tumor

0.516

Nicotine abuse

79

Mann–Whitney Rank Sum

nicotine vs. no nicotine

0.358

Alcohol abuse

79

Mann–Whitney Rank Sum

alcohol vs. no alcohol

0.743

Progression free survival

81

Kaplan-Meier

CCNA1 <4 vs. ≥4

0.363

Overall survival

81

Kaplan-Meier

CCNA1 <4 vs. ≥4

0.354

HPV16 DNA status

81

Mann–Whitney Rank Sum

HPV16+ vs. HPV16-

0.001

E6 quantitative

37

Spearman Rank Order

σ = 0.229

0.172

E7 quantitative

37

Spearman Rank Order

σ = 0.250

0.134

P16 Expression

79

Spearman Rank Order

σ = 0.376

0.0007

P53 Expression

80

Spearman Rank Order

σ = −0.086

0.448

P53 Mutation

41

Mann–Whitney Rank Sum

P53 mutated vs. wild-type

0.920

Cyclin A1 Methylation

44

Mann–Whitney Rank Sum

methylated vs. non-methylated

0.882

  1. N: number of available samples; CUP: Carcinoma of unknown primary; Age in years [y]; stage: UICC-stage; T: Tumor size: T1 (< 2 cm), T2 (2-4 cm), T3 (> 4 cm), T4 (Tumor infiltrates adjacent structures); N: status of regional lymph node metastasis: N0 (no metastasis), N1 (single ipsilateral lymph node metastasis, size < 3 cm), N2a (single ipsilateral lymph node metastasis, size 3-6 cm), N2b (multiple ipsilateral lymph node metastases, size 3-6 cm), N2c (multiple ipsi- and contralateral lymph node metastases, size 3-6 cm), N3 (lymph node metastasis, size > 6 cm); E6/E7 quantitative: results of quantitative HPV16 Real-Time PCR; CCNA1: Cyclin A1; CCNA1 <4/≥4: immunohistochemical expression of Cyclin A1 less than 20% or at least 20%.
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BMC Cancer

ISSN: 1471-2407

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