Cyclin A1 shows age-related expression in benign tonsils, HPV16-dependent overexpression in HNSCC and predicts lower recurrence rate in HNSCC independently of HPV16

Table 3 Correlation of Cyclin A1 expression in immunohistochemistry with clinicopathological characteristics in controls (tonsils)

Clinicopathological parameter	N	Performed Statistic	Subgroups	P
Age [y]	74	Spearman Rank Order	σ = −0.512	0.000004
Sex	74	Mann–Whitney Rank Sum	male vs. female	0.899
Nicotine abuse	74	Mann–Whitney Rank Sum	nicotine vs. no nicotine	0.012
Alcohol abuse	74	Mann–Whitney Rank Sum	alcohol vs. no alcohol	0.160
P16 Expression	74	Spearman Rank Order	σ = 0.336	0.005
P53 Expression	74	Spearman Rank Order	σ = 0.419	0.0002
Cyclin A1 Methylation	12	Mann–Whitney Rank Sum	methylated vs. non-methylated	0.386

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