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Table 2 Prevalence of HPV16 positivity in Real-Time PCR and overexpression of p16 in immunohistochemistry with respect to primary site

From: Cyclin A1 shows age-related expression in benign tonsils, HPV16-dependent overexpression in HNSCC and predicts lower recurrence rate in HNSCC independently of HPV16

Primary site

N

HPV16 positive RT-PCR

P16 overexpression

abs.

%

P

abs.

%

P

Tonsil

33

19

57.6

0.112

15/32*

46.9

0.492

Base of the tongue

28

17

60.7

0.062

15/27*

55.6

0.094

Oropharynx (Tonsil and base of the tongue)

61

36

50.0

< 0.001

30/59*

50.8

0.008

Anterior two-thirds of the tongue

9

1

11.1

0.035

2

22.2

0.291

Floor of the mouth

2

0

0.0

0.498

0

0.0

0.507

Hypopharynx

1

0

0.0

1.000

0

0.0

1.000

Soft palate

2

0

0.0

0.498

0

0.0

0.507

Supraglottic

3

0

0.0

0.246

1

33.3

1.000

Unknown (CUP)

3

0

0.0

0.246

0

0.0

0.261

  1. *P16 immunohistochemistry was done in 79 of 81 cases.