Skip to main content

Table 2 Prevalence of HPV16 positivity in Real-Time PCR and overexpression of p16 in immunohistochemistry with respect to primary site

From: Cyclin A1 shows age-related expression in benign tonsils, HPV16-dependent overexpression in HNSCC and predicts lower recurrence rate in HNSCC independently of HPV16

Primary site N HPV16 positive RT-PCR P16 overexpression
abs. % P abs. % P
Tonsil 33 19 57.6 0.112 15/32* 46.9 0.492
Base of the tongue 28 17 60.7 0.062 15/27* 55.6 0.094
Oropharynx (Tonsil and base of the tongue) 61 36 50.0 < 0.001 30/59* 50.8 0.008
Anterior two-thirds of the tongue 9 1 11.1 0.035 2 22.2 0.291
Floor of the mouth 2 0 0.0 0.498 0 0.0 0.507
Hypopharynx 1 0 0.0 1.000 0 0.0 1.000
Soft palate 2 0 0.0 0.498 0 0.0 0.507
Supraglottic 3 0 0.0 0.246 1 33.3 1.000
Unknown (CUP) 3 0 0.0 0.246 0 0.0 0.261
  1. *P16 immunohistochemistry was done in 79 of 81 cases.