Does risk for ovarian malignancy algorithm excel human epididymis protein 4 and ca125 in predicting epithelial ovarian cancer: A meta-analysis

Table 2 QUADAS-2 quality items results

Study ID	Risk of Bias				Concerns Regarding Applicability
	PATIENT SELECTION	INDEX TEST	REFERENCE STANDARD	FLOW & TIMING	PATIENT SELECTION	INDEX TEST			REFERENCE STANDARD
						HE4	CA125	ROMA
Abdel-Azeez et al., 2010	?	?	?	?	☺	☺	☺	-	☺
Bandiera et al., 2011	☻	?	?	☻	☻	☻	☺	☻	☺
Chang et al., 2011	?	☺	☺	?	☺	☺	☻	-	?
Holcomb et al., 2011	☻	☺	☺	☻	?	☻	☺	-	☺
Jacob et al., 2011	?	☺	☺	☻	?	☺	☻	☻	☺
Kim et al., 2011	☺	☺	☺	☺	☺	☻	☺	☻	☺
Montagnana et al., 2011	☺	?	☺	☺	☺	☺	☺	☺	☺
Moore et al., 2008	?	☻	☺	☺	☺	☺	☻	-	☺
Moore et al. 2009	☺	?	☺	☻	☺	☺	☺	☺	☺
Moore et al., 2011	?	☺	☺	☻	☺	☺	☺	☺	☺
Van Gorp et al. 2011	☺	☺	☺	☺	☺	☺	☻	☻	☺

ROMA: Risk of Ovarian Malignancy Algorithm; HE4: Human Epididymis Protein 4; CA125: Cancer Antigen 125.
☺: low risk; ☻: high risk; ?: unclear risk.

ISSN: 1471-2407