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Table 1 Distribution of the SULT1A1 rs9282861 genotypes in relation to the subject characteristics§

From: SULT1A1 rs9282861 polymorphism-a potential modifier of efficacy of the systemic adjuvant therapy in breast cancer?

   rs9282861 genotype
Characteristics All subjects (n = 412) GG (n = 121) AG (n = 194) AA (n = 97)
Age at diagnosis, years     
   ≤ 39 37 (9.0) 14 (37.8) 15 (40.5) 8 (21.6)
   40-49 98 (23.8) 34 (34.7) 40 (40.8) 24 (24.5)
   50-59 104 (25.2) 29 (27.9) 51 (49.0) 24 (23.1)
   60-69 65 (15.8) 16 (24.6) 36 (55.4) 13 (20.0)
   ≥ 70 108 (26.2) 28 (25.9) 52 (48.1) 28 (25.9)
T stage (UICC)     
   1 215 (52.2) 59 (27.4) 101 (47.0) 55 (25.6)
   2 164 (39.8) 56 (34.1) 73 (44.5) 35 (21.3)
   3 22 (5.3) 3 (13.6) 15 (68.2) 4 (18.2)
   4 11 (2.7) 3 (27.3) 5 (45.5) 3 (27.3)
Nodal status (UICC)     
   N- 247 (60.0) 67 (27.1) 117 (47.4) 63 (25.5)
   N+ 165 (40.0) 54 (32.7) 77 (46.7) 34 (20.6)
Stage (UICC)     
   I 165 (40.0) 46 (27.9) 79 (47.9) 40 (24.2)
   II 210 (51.0) 68 (32.4) 92 (43.8) 50 (23.8)
   III 37 (9.0) 7 (18.9) 23 (62.2) 7 (18.9)
Oestrogen receptor status     
   Positive 310 (75.2) 88 (28.4) 146 (47.1) 76 (24.5)
   Negative 89 (21.6) 28 (31.5) 45 (50.6) 16 (18.0)
   Unknown 13 (3.2) 5 (38.5) 3 (23.1) 5 (38.5)
Progesterone receptor status     
   Positive 247 (60.0) 71 (28.7) 113 (45.7) 63 (25.5)
   Negative 150 (36.4) 45 (30.0) 76 (50.7) 29 (19.3)
   Unknown 15 (3.6) 5 (33.3) 5 (33.3) 5 (33.3)
Morphological type     
   Ductal 268 (65.0) 75 (28.0) 132 (49.3) 61 (22.8)
   Lobular 70 (17.0) 28 (40.0) 27 (38.6) 15 (21.4)
   Other types 74 (18.0) 18 (24.3) 35 (47.3) 21 (28.4)
Adjuvant treatment     
   Radiotherapy 243 (59.0) 74 (30.5) 110 (45.3) 59 (24.3)
   Endocrine therapy 106 (25.7) 28 (26.4) 56 (52.8) 22 (20.8)
Tamoxifen 88 (21.4) 23 (26.1) 45 (51.1) 20 (22.7)
Toremifen 17 (4.1) 5 (29.4) 11 (64.7) 1 (5.9)
Chemotherapy 80 (19.4) 34 (42.5) 31 (38.8) 15 (18.8)
Vital Status     
   Alive 184 (44.7) 50 (27.2) 88 (47.8) 46 (25.0)
No recurrence 159 (38.6) 41 (25.8) 79 (49.7) 39 (24.5)
Recurrence of breast cancer 25 (6.1) 9 (36.0) 9 (36.0) 7 (28.0)
Death 228 (55.3) 71 (31.1) 106 (46.5) 51 (22.4)
   Breast cancer caused death 112 (27.2) 40 (35.7) 49 (43.8) 23 (20.5)
   Death with other reasons 116 (28.2) 31 (26.7) 57 (49.1) 28 (24.1)
  1. §Values in the table are number of patients (%).
  2. UICC = International Union Against Cancer, TNM Classification of Malignant Tumours, Fourth, Fully Revised Edition