Table 1 Pathology observed grossly, by anatomical site
From: Menin and p53 have non-synergistic effects on tumorigenesis in mice
Men1 +/+;Trp53 +/+ | Men1 +/+;Trp53 +/− | Men1 +/+;Trp53 −/− | Men1 +/−;Trp53 +/+ | Men1 +/−;Trp53 +/− | Men1 +/−;Trp53 −/− | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Pituitary | 4/13 | (30.8%) | 0/9 | 0 | 1/13 | (7.7%) | 14/19 | (73.7%) | 11/21 | (52.4%) | 5/28 | (17.9%) |
Pancreas | 0/13 | 0 | 1/9 | (11.1%) | 1/13 | (7.7%) | 13/19 | (68.4%) | 12/22 | (54.5%) | 4/28 | (14.3%) |
Thyroid | 3/11 | (27.3%) | 0/8 | 0 | 0/11 | 0 | 5/17 | (29.4%) | 9/22 | (40.9%) | 4/27 | (14.8%) |
Parathyroid | 1/11 | (9.1%) | 1/8 | (12.5%) | 0/11 | 0 | 4/17 | (23.5%) | 5/22 | (22.7%) | 0/27 | 0 |
Thymus | 0/13 | 0 | 0/9 | 0 | 3/13 | (23.1%) | 1/19 | (5.9%) | 2/22 | (9.1%) | 11/28 | (39.3%) |
Lymph Nodes | 2/13 | (15.3%) | 3/9 | (33.3%) | 9/13 | (69.2%) | 4/19 | (21.1%) | 9/22 | (40.1%) | 20/28 | (71.4%) |
Spleen | 1/13 | (7.7%) | 1/9 | (11.1%) | 7/13 | (53.8%) | 3/19 | (15.8%) | 4/22 | (18.2%) | 21/28 | (75.0%) |
Muscle | 0/13 | 0 | 1/9 | (11.1%) | 5/13 | (38.5%) | 1/19 | (5.3%) | 3/22 | (13.6%) | 6/28 | (21.4%) |
Bone | 0/13 | 0 | 3/9 | (33.3%) | 0/13 | 0 | 3/19 | (15.8%) | 2/22 | (9.1%) | 1/28 | (3.6%) |
Bladder/Urethra | 0/13 | 0 | 2/9 | (22.2%) | 0/13 | 0 | 0/19 | 0 | 0/22 | 0 | 1/27 | (3.7%) |
Prostate/Seminal Vesicles | 2/5 | (40.0%) | 2/6 | (33.3%) | 1/5 | (20.0%) | 1/9 | (11.1%) | 4/12 | (33.3%) | 1/15 | (6.7%) |
Testes | 0/5 | 0 | 1/6 | (16.7%) | 1/5 | (20.0%) | 5/9 | (55.6%) | 7/12 | (58.3%) | 2/16 | (12.5%) |
Uterus | 3/8 | (37.5%) | 2/3 | (66.7%) | 0/8 | 0 | 2/10 | (20.0%) | 0/10 | 0 | 0/11 | 0 |
Ovaries | 0/8 | 0 | 1/3 | (33.3%) | 1/8 | (12.5%) | 5/10 | (50.0%) | 6/10 | (60.0%) | 5/11 | (45.5%) |
Mammary Glands | 1P/13 | (7.7%) | 0/9 | 0 | 0/6 | 0 | 1 L/18 | (5.6%) | 1 L,1P/17 (5.9%L,5.9%P) | 0/14 | 0 | |
Adrenal Glands | 0/13 | 0 | 1/8 | (12.5%) | 3/13 | (23.1%) | 5/18 | (27.8%) | 9/21 | (42.6%) | 6/28 | (21.4%) |
Lung | 3/13 | (23.1%) | 1/9 | (11.1%) | 3/13 | (23.1%) | 2/19 | (10.5%) | 4/21 | (19.0%) | 3/28 | (10.7%) |
Liver | 1/13 | (7.7%) | 3/9 | (33.3%) | 3/13 | (23.1%) | 1/19 | (5.3%) | 2/21 | (9.5%) | 6/28 | (21.4%) |