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Table 2 Relative and absolute risks of subsequent tobacco-related primary cancer according to type of first tobacco-related primary cancer and sex (Bavaria; 2002–2008)

From: Risk of tobacco-related multiple primary cancers in Bavaria, Germany

    Men   Women
First tobacco-related primary cancer Subsequent tobacco-related primary cancer O SIR (95% CI) EAR O SIR (95% CI) EAR
mouth, pharynx oesophagus 86 19.63 (15.71-24.25) 45.6 15 48.06 (26.9-79.27) 24.7
  stomach 24 2.87 (1.84-4.27) 8.7 2 0.93 (0.11-3.35) −0.3
  colon, rectum 54 1.65 (1.24-2.15) 11.9 12 1.42 (0.74-2.49) 6.0
  pancreas 9 1.36 (0.62-2.58) 1.3 2 0.92 (0.11-3.31) −0.3
  larynx 43 14.10 (10.21-18.99) 22.3 7 69.05 (27.76-142.26) 11.6
  bronchus, lung 201 7.90 (6.85-9.07) 98.1 42 12.36 (8.91-16.71) 65.0
  kidney 17 2.11 (1.23-3.38) 5.0 2 1.27 (0.15-4.60) 0.7
  urinary tract 3 2.82 (0.58-8.24) 1.1 - - -
  urinary bladder 18 1.28 (0.76-2.02) 2.2 2 1.18 (0.14-4.28) 0.5
  leukemia 14 3.03 (1.66-5.09) 5.2 2 1.59 (0.19-5.75) 1.25
oesophagus mouth, pharynx 36 14.18 (9.93-19.64) 70.3 5 34.92 (11.34-81.48) 49.4
  stomach 5 1.64 (0.53-3.82) 4.1 1 2.41 (0.06-13.42) 6.0
  colon, rectum 23 1.99 (1.26-2.98) 24.0 6 3.70 (1.36-8.05) 44.5
  pancreas 5 2.15 (0.70-5.01) 5.6 2 4.71 (0.57-17.00) 16.0
  larynx 7 7.44 (2.99-15.33) 12.7 - - -
  bronchus, lung 23 2.62 (1.66-3.92) 29.9 6 9.42 (3.46-20.50) 54.5
  kidney 8 2.97 (1.28-5.86) 11.2 2 6.54 (0.79-23.62) 17.2
  urinary tract 1 2.53 (0.06-14.12) 1.3 - - -
  urinary bladder 12 2.34 (1.21-4.09) 14.4 1 3.07 (0.08-17.13) 6.9
  leukemia 6 3.65 (1.34-7.94) 9.2 - - -
stomach mouth, pharynx 6 0.97 (0.36-2.12) −0.1 1 0.70 (0.02-3.91) −0.4
  oesophagus 8 2.07 (0.90-4.09) 3.3 1 1.56 (0.04-8.71) 0.4
  colon, rectum 68 1.68 (1.30-2.13) 21.8 40 1.86 (1.33-2.54) 18.9
  pancreas 17 2.09 (1.22-3.34) 7.0 13 2.24 (1.19-3.83) 7.3
  larynx 3 1.18 (0.24-3.43) 0.4 - - -
  bronchus, lung 33 1.15 (0.79-1.62) 3.5 9 1.34 (0.61-2.54) 2.3
  kidney 19 2.26 (1.36-3.53) 8.4 6 1.66 (0.61-3.62) 2.4
  urinary tract 1 0.65 (0.02-3.64) −0.4 - - -
  urinary bladder 17 0.87 (0.51-1.39) −2.0 3 0.69 (0.14-2.01) −1.4
  leukemia 11 1.80 (0.90-3.22) 3.9 6 1.88 (0.69-4.09) 2.9
colon, rectum mouth, pharynx 56 1.48 (1.12-1.92) 2.5 13 1.50 (0.80-2.56) 0.7
  oesophagus 31 1.33 (0.91-1.89) 1.1 8 2.07 (0.89-4.08) 0.7
  stomach 73 1.11 (0.87-1.40) 1.0 45 1.31 (0.96-1.75) 1.8
  pancreas 43 0.92 (0.66-1.23) −0.5 44 1.30 (0.94-1.74) 1.7
  larynx 15 0.97 (0.54-1.60) −0.1 - - -
  bronchus, lung 210 1.26 (1.09-1.44) 5.8 60 1.47 (1.12-1.89) 3.3
  kidney 85 1.71 (1.37-2.12) 4.8 36 1.67 (1.17-2.31) 2.5
  urinary tract 12 1.40 (0.72-2.44) 0.5 7 1.86 (0.75-3.84) 0.6
  urinary bladder 148 1.34 (1.13-1.58) 5.1 38 1.49 (1.06-2.05) 2.1
  leukemia 59 1.71 (1.3-2.21) 3.3 32 1.73 (1.18-2.44) 2.3
pancreas mouth, pharynx 1 0.47 (0.01-2.59) −2.7 1 1.77 (0.04-9.87) 1.1
  oesophagus 1 0.80 (0.02-4.48) −0.6 - - -
  stomach 9 2.91 (1.33-5.52) 14.1 7 3.60 (1.45-7.42) 12.7
  colon, rectum 16 1.41 (0.81-2.29) 11.1 12 1.63 (0.84-2.84) 11.6
  larynx 3 3.57 (0.74-10.43) 5.2 - - -
  bronchus, lung 10 1.18 (0.57-2.18) 3.7 3 1.12 (0.23-3.26) 0.8
  kidney 4 1.58 (0.43-4.04) 3.5 4 2.88 (0.79-7.39) 6.6
  urinary bladder 7 1.36 (0.55-2.81) 4.5 - - -
  leukemia 1 0.61 (0.02-3.40) −1.5 2 1.82 (0.22-6.58) 2.26
larynx mouth, pharynx 33 8.83 (6.08-12.41) 41.9 3 26.52 (5.47-77.51) 34.8
  oesophagus 18 8.92 (5.28-14.09) 22.9 1 23.53 (0.60-131.09) 11.6
  stomach 5 1.10 (0.36-2.57) 0.7 1 3.95 (0.10-22.03) 9.0
  colon, rectum 18 1.05 (0.63-1.67) 1.3 - - -
  pancreas 9 2.61 (1.19-4.95) 7.9 1 3.74 (0.09-20.82) 8.8
  bronchus, lung 69 5.37 (4.18-6.80) 80.4 9 18.83 (8.61-35.75) 102.9
  kidney 6 1.53 (0.56-3.32) 3.0 - - -
  urinary tract 1 1.71 (0.04-9.53) 0.6 - - -
  urinary bladder 10 1.31 (0.63-2.41) 3.4 1 4.79 (0.12-26.68) 9.6
  leukemia 2 0.82 (0.10-2.97) −0.6 - - -
bronchus, lung mouth, pharynx 42 3.48 (2.51-4.71) 13.1 10 6.46 (3.10-11.88) 7.5
  oesophagus 20 2.83 (1.73-4.37) 5.6 3 4.84 (1.00-14.14) 2.1
  stomach 28 1.60 (1.06-2.31) 4.6 12 2.88 (1.49-5.03) 6.9
  colon, rectum 71 1.10 (0.86-1.39) 2.8 17 1.02 (0.59-1.63) 0.3
  pancreas 19 1.47 (0.89-2.30) 2.7 10 2.31 (1.11-4.24) 5.0
  larynx 37 7.78 (5.48-10.72) 14.1 1 4.94 (0.12-27.50) 0.7
  kidney 32 2.21 (1.51-3.12) 7.6 13 3.94 (2.10-6.74) 8.6
  urinary tract 6 2.62 (0.96-5.71) 1.6 3 5.93 (1.22-17.33) 2.2
  urinary bladder 63 2.15 (1.65-2.75) 14.7 9 2.69 (1.23-5.11) 5.0
  leukemia 16 1.72 (0.98-2.80) 2.9 3 1.21 (0.25-3.53) 0.5
kidney mouth, pharynx 10 1.11 (0.53-2.03) 0.5 1 0.62 (0.02-3.44) −0.5
  oesophagus 4 0.76 (0.21-1.95) −0.7 - - -
  stomach 15 1.14 (0.64-1.89) 1.1 5 0.90 (0.29-2.09) −0.5
  colon, rectum 51 1.06 (0.79-1.39) 1.5 25 1.17 (0.76-1.73) 3.2
  pancreas 9 0.93 (0.42-1.76) −0.4 5 0.87 (0.28-2.02) −0.7
  larynx 3 0.86 (0.18-2.50) −0.3 1 5.08 (0.13-28.28) 0.7
  bronchus, lung 54 1.51 (1.13-1.97) 10.1 16 2.06 (1.18-3.34) 7.1
  urinary tract 3 1.75 (0.36-5.12) 0.7 3 4.47 (0.92-13.07) 2.0
  urinary bladder 51 2.31 (1.72-3.03) 16.1 10 2.29 (1.10-4.21) 4.9
  leukemia 12 1.72 (0.89-3.00) 2.8 2 0.63 (0.08-2.28) −1.0
urinary tract oesophagus 1 1.64 (0.04-9.15) 2.0 - - -
  stomach 2 1.05 (0.13-3.80) 0.5 - - -
  colon, rectum 12 1.84 (0.95-3.21) 28.5 4 1.21 (0.33-3.10) 4.9
  pancreas 3 2.28 (0.47-6.66) 8.8 3 3.35 (0.69-9.78) 14.7
  bronchus, lung 9 1.96 (0.89-3.72) 22.9 4 3.82 (1.04-9.77) 20.7
  kidney 4 2.97 (0.81-7.60) 13.8 - - -
  urinary bladder 5 1.58 (0.51-3.68) 9.5 12 17.84 (9.22-31.15) 79.3
  leukemia 2 2.03 (0.25-7.32) 5.3 - - -
urinary bladder mouth, pharynx 25 1.41 (0.91-2.08) 2.0 3 1.63 (0.34-4.77) 1.0
  oesophagus 12 1.05 (0.54-1.83) 0.2 3 3.60 (0.74-10.53) 1.8
  stomach 41 1.13 (0.81-1.53) 1.3 16 2.10 (1.20-3.40) 6.8
  colon, rectum 144 1.16 (0.98-1.36) 5.5 26 0.95 (0.62-1.39) −1.2
  pancreas 31 1.24 (0.84-1.75) 1.7 6 0.80 (0.29-1.74) −1.2
  larynx 4 0.53 (0.15-1.36) −1.0 - - -
  bronchus, lung 187 2.16 (1.86-2.49) 27.9 25 2.87 (1.85-4.23) 13.3
  kidney 77 3.04 (2.40-3.80) 14.4 12 2.56 (1.32-4.48) 6.0
  urinary tract 7 1.47 (0.59-3.03) 0.6 6 7.26 (2.66-15.79) 4.2
  leukemia 30 1.59 (1.07-2.27) 3.1 8 1.96 (0.85-3.87) 3.2
leukemia mouth, pharynx 3 0.73 (0.15-2.13) −1.2 2 2.42 (0.29-8.73) 1.8
  oesophagus 5 2.10 (0.68-4.89) 2.9 - - -
  stomach 9 1.43 (0.66-2.72) 3.0 4 1.50 (0.41-3.84) 2.0
  colon, rectum 27 1.19 (0.79-1.74) 4.8 14 1.37 (0.75-2.30) 5.8
  pancreas 6 1.32 (0.48-2.87) 1.6 4 1.48 (0.40-3.78) 2.0
  larynx 1 0.63 (0.02-3.48) −0.7 - - -
  bronchus, lung 27 1.63 (1.08-2.38) 11.5 7 1.83 (0.74-3.77) 4.8
  kidney 7 1.40 (0.56-2.89) 2.2 - - -
  urinary tract 3 3.68 (0.76-10.76) 2.4 - - -
  urinary bladder 11 1.05 (0.52-1.87) 0.5 4 1.94 (0.53-4.97) 3.0
  1. O, number of observed cases; SIR, standardized incidence ratio; 95% CI, 95% confidence interval; EAR, excess absolute risk per 10,000; bold type, SIR significantly different from one.