Cholesterol and the risk of grade-specific prostate cancer incidence: evidence from two large prospective cohort studies with up to 37 years' follow up

Table 2 Unadjusted hazard ratios and 95% CI for overall and Gleason-specific prostate cancer by cholesterol quintiles among Midspan subjects who survived until 1^st January 1997. N = 6486.

	All Prostate cancer				Gleason < 7				Gleason 7				Gleason ≥8				Unknown
*Cholesterol (mmol/L) quintiles*		(n)	Hazard Ratio (95%CI)		%	(n)	Hazard Ratio (95%CI)		%	(n)	Hazard Ratio (95%CI)		%	(n)	Hazard Ratio (95%CI)		%	(n)	Hazard Ratio (95%CI)
< 5.05	1,384	(61)		1	24.6	(15)		1	21.3	(13)		1	27.9	(17)		1	26.2	(16)		1
5.06 - < 5.57	1,308	(51)	0.87	(0.60, 1.26)	17.6	(9)	0.62	(0.27,1.41)	13.7	(7)	0.54	(0.22,1.36)	37.3	(19)	1.18	(0.61, 2.27)	31.4	(16)	1.04	(0.52, 2.09)
5.58 - < 6.09	1,425	(65)	1.03	(0.72, 1.46)	26.2	(17)	1.1	(0.56,2.27)	12.3	(8)	0.59	(0.24,1.42)	26.2	(30)	1.70	(0.93, 3.07)	15.4	(10)	0.59	(0.27, 1.31)
6.1 - < 6.69	1,159	(71)	1.36	(0.97, 1.92)	16.9	(12)	0.96	(0.45,2.05)	18.3	(13)	1.14	(0.53,2.47)	46.5	(33)	2.28	(1.27, 4.10)	18.3	(13)	0.95	(0.46, 1.98)
≥6.7	1,210	(59)	1.09	(0.76, 1.57)	18.6	(11)	0.83	(0.38,1.81)	27.1	(16)	1.35	(0.65,2.81)	33.9	(20)	1.34	(0.70, 2.57)	20.3	(12)	0.85	(0.40, 1.80)

Univariate hazard ratios and 95% confidence intervals were estimated within a model employing age as time-scale