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Table 1 Methylation status of miR CpG islands in gastric mucosa samples with different pathological changes in GC and non-cancerous control patients

From: Characterization of human gastric carcinoma-related methylation of 9 miR CpG islands and repression of their expressions in vitro and in vivo

miRCpG islands

Group of gastric samples

miR-Methylation

Positive rate

Proportion (%) of methylated miRin the miRmethylation-positive samples

Positive rate (%)

χ 2-value

Trend-test (P-value)

Median[25% ~ 75%]

Mean±SD

t/F/χ 2-value

P-value

miR-9-1

Normal

1/13 (7.7)

27.598

<0.001 a

NA

  

NA

 

Gastritis

1/35 (2.9)

  

NA

   
 

SM

9/28 (32.1)

  

17 [13–30]

20 ± 4

t = −3.039

0.005 g

 

GC

18/28 (64.3)

  

29 [19–40]

32 ± 4

  

miR-9-3

Normal

6/13 (46.2)

23.389

<0.001 a

38 [31–59]

43 ± 6

F = 1.639

0.189 h

 

Gastritis

15/37 (40.5)

  

43 [36–48]

42 ± 2

  
 

SM

26/28 (92.9)

  

38 [26–44]

36 ± 2

  
 

GC

26/28 (92.9)

  

37 [26–43]

36 ± 2

  

miR-137

Normal

5/13 (38.5)

18.626

<0.001 a

10 [4–41]

 

χ 2 = 8.065

0.045 d

 

Gastritis

24/38 (63.2)

  

19 [7–36]

   
 

SM

25/26 (96.4)

  

15 [7–40]

21 ± 3g

  
 

GC

24/26 (92.3)

  

36 [20–51]

37 ± 4

  

miR-34b

Normal

6/13 (46.2)

6.947

0.008 a

13 [7–19]

 

χ 2 = 0.658

0.883 d

 

Gastritis

13/36 (36.1)

  

11 [3–20]

   
 

SM

22/28 (78.6)

  

11 [4–18]

   
 

GC

19/28 (67.9)

  

10 [5–32]

   

miR-200b

Normal

13/13 (100)

0.486

0.922 f

54 [52–83]

 

χ 2 = 17.883

<0.001 d

 

Gastritis

35/36 (97.2)

  

52 [46–100] e

   
 

SM

27/28 (96.4)

  

44 [40–47]

   
 

GC

27/28 (96.4)

  

48 [40–53]

   

miR-210

Normal

2/13 (15.4)

11.908

0.001 a

NA

  

NA

 

Gastritis

13/38 (34.2)

  

7 [5–10]

   
 

SM

22/27 (81.5)

  

11 [5–22]

   
 

GC

16/27 (59.3)

  

9 [4–16]

   

miR-193b

Normal

0/13

7.045

0.008 b

NA

  

NA

 

Gastritis

2/37 (5.4)

  

NA

   
 

SM

7/28 (25.0)

  

5 [4–14]

   
 

GC

4/28 (14.3)

  

5 [2–12]

   

miR-203

Normal

5/13 (38.5)

5.617

0.018 b

32 [29–75]

 

χ 2 = 2.957

0.398 d

 

Gastritis

20/38 (52.6)

  

31 [26–36]

   
 

SM

21/28 (75.0)

  

34 [30–36]

   
 

GC

11/28 (39.3)c

  

32 [29–35]

   

miR-375

Normal

0/13

12.266

<0.001 b

NA

  

NA

 

Gastritis

13/38 (34.2)

  

3 [3–4] e

   
 

SM

16/28 (57.1)

  

7 [4–14]

   
 

GC

8/28 (28.6) c

  

17 [8–21]

   
  1. a, Trend test, among Normal, Gastritis, SM and GC samples; b, Trend-test, among Normal, Gastritis, and SM samples; c, Pearson’s Chi-square test, GC versus SM: miR-203, χ 2 = 7.292, P = 0.007; miR-375, χ 2 = 4.667, P = 0.031; d, Kruskal-Wallis H-test; e, Mann–Whitney U-test: Gastritis versus SM, miR-200b,U = 230.000, P = 0.001; Gastritis versus GC, miR-375, U = 46.000, P = 0.011; SM versus GC, miR-137, U = 170.000, P = 0.009; f, Pearson’s Chi-square test, among Normal, Gastritis, SM and GC samples; g. Paired t-test: SM versus GC, miR-137, t = −2.652, P = 0.014; h. One-way ANOVA; NA, not available.