Skip to main content

Table 1 Methylation status of miR CpG islands in gastric mucosa samples with different pathological changes in GC and non-cancerous control patients

From: Characterization of human gastric carcinoma-related methylation of 9 miR CpG islands and repression of their expressions in vitro and in vivo

miRCpG islands Group of gastric samples miR-Methylation
Positive rate Proportion (%) of methylated miRin the miRmethylation-positive samples
Positive rate (%) χ 2-value Trend-test (P-value) Median[25% ~ 75%] Mean±SD t/F/χ 2-value P-value
miR-9-1 Normal 1/13 (7.7) 27.598 <0.001 a NA    NA
  Gastritis 1/35 (2.9)    NA    
  SM 9/28 (32.1)    17 [13–30] 20 ± 4 t = −3.039 0.005 g
  GC 18/28 (64.3)    29 [19–40] 32 ± 4   
miR-9-3 Normal 6/13 (46.2) 23.389 <0.001 a 38 [31–59] 43 ± 6 F = 1.639 0.189 h
  Gastritis 15/37 (40.5)    43 [36–48] 42 ± 2   
  SM 26/28 (92.9)    38 [26–44] 36 ± 2   
  GC 26/28 (92.9)    37 [26–43] 36 ± 2   
miR-137 Normal 5/13 (38.5) 18.626 <0.001 a 10 [4–41]   χ 2 = 8.065 0.045 d
  Gastritis 24/38 (63.2)    19 [7–36]    
  SM 25/26 (96.4)    15 [7–40] 21 ± 3g   
  GC 24/26 (92.3)    36 [20–51] 37 ± 4   
miR-34b Normal 6/13 (46.2) 6.947 0.008 a 13 [7–19]   χ 2 = 0.658 0.883 d
  Gastritis 13/36 (36.1)    11 [3–20]    
  SM 22/28 (78.6)    11 [4–18]    
  GC 19/28 (67.9)    10 [5–32]    
miR-200b Normal 13/13 (100) 0.486 0.922 f 54 [52–83]   χ 2 = 17.883 <0.001 d
  Gastritis 35/36 (97.2)    52 [46–100] e    
  SM 27/28 (96.4)    44 [40–47]    
  GC 27/28 (96.4)    48 [40–53]    
miR-210 Normal 2/13 (15.4) 11.908 0.001 a NA    NA
  Gastritis 13/38 (34.2)    7 [5–10]    
  SM 22/27 (81.5)    11 [5–22]    
  GC 16/27 (59.3)    9 [4–16]    
miR-193b Normal 0/13 7.045 0.008 b NA    NA
  Gastritis 2/37 (5.4)    NA    
  SM 7/28 (25.0)    5 [4–14]    
  GC 4/28 (14.3)    5 [2–12]    
miR-203 Normal 5/13 (38.5) 5.617 0.018 b 32 [29–75]   χ 2 = 2.957 0.398 d
  Gastritis 20/38 (52.6)    31 [26–36]    
  SM 21/28 (75.0)    34 [30–36]    
  GC 11/28 (39.3)c    32 [29–35]    
miR-375 Normal 0/13 12.266 <0.001 b NA    NA
  Gastritis 13/38 (34.2)    3 [3–4] e    
  SM 16/28 (57.1)    7 [4–14]    
  GC 8/28 (28.6) c    17 [8–21]    
  1. a, Trend test, among Normal, Gastritis, SM and GC samples; b, Trend-test, among Normal, Gastritis, and SM samples; c, Pearson’s Chi-square test, GC versus SM: miR-203, χ 2 = 7.292, P = 0.007; miR-375, χ 2 = 4.667, P = 0.031; d, Kruskal-Wallis H-test; e, Mann–Whitney U-test: Gastritis versus SM, miR-200b,U = 230.000, P = 0.001; Gastritis versus GC, miR-375, U = 46.000, P = 0.011; SM versus GC, miR-137, U = 170.000, P = 0.009; f, Pearson’s Chi-square test, among Normal, Gastritis, SM and GC samples; g. Paired t-test: SM versus GC, miR-137, t = −2.652, P = 0.014; h. One-way ANOVA; NA, not available.