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Table 4 Correlations between tamoxifen metabolite concentrations in tumor tissue and serum.

From: Steroid receptor coactivators, HER-2 and HER-3 expression is stimulated by tamoxifen treatment in DMBA-induced breast cancer

  

Tam

4OHtam

4OHNDtam

NDtam

NDDtam

TamNox

  

Tumor

Serum

Tumor

Serum

Tumor

Serum

Tumor

Serum

Tumor

Serum

Tumor

Serum

Tam

             

Tumor

r

-

           
 

n

-

           

Serum

r

0.70

-

          
 

n

5

-

          

4OHtam

            

Tumor

r

1.00**

0.70

-

         
 

n

5

5

-

         

Serum

r

−0.70

−0.19

−0.70

-

        
 

n

5

8

5

-

        

4OHNDtam

            

Tumor

r

1.00**

0.70

1.00**

−0.70

-

       
 

n

5

5

5

5

-

       

Serum

r

−0.60

0.41

−0.60

−0.31

−0.60

-

      
 

n

5

8

5

8

5

-

      

NDtam

             

Tumor

r

1.00**

0.70

1.00**

−0.70

1.00**

−0.60

-

     
 

n

5

5

5

5

5

5

-

     

Serum

r

−0.70

0.14

−0.70

0.00

−0.70

0.91**

−0.70

-

    
 

n

5

8

5

8

5

8

5

-

    

NDDtam

             

Tumor

r

0.40

0.60

0.40

−0.10

0.40

−0.20

0.40

−0.60

-

   
 

n

5

5

5

5

5

5

5

5

-

   

Serum

r

−0.50

−0.12

−0.50

−0.24

−0.50

−0.52

−0.50

−0.48

0.40

-

  
 

n

5

8

5

8

5

8

5

8

5

-

  

TamNox

             

Tumor

r

0.80

0.50

0.80

−0.50

0.80

−0.60

0.80

−0.50

−0.10

−0.70

-

 
 

n

5

5

5

5

5

5

5

5

5

5

-

 

Serum

r

0.90*

0.41

0.90*

0.24

0.90*

0.43

0.90*

0.55

0.30

−0.21

0.90*

-

 

n

5

8

5

8

5

8

5

8

5

8

5

-

  1. Spearman’s nonparametric test. Correlation coefficients (r) are presented in the table.
  2. Significant correlations are indicated by italics and * = P < 0.05 or ** = P < 0.01.
  3. Tam = tamoxifen; 4OHtam = 4-hydroxytamoxifen; 4OHNDtam = 4-hydroxy-N-desmethyltamoxifen; NDtam = N-desmethyltamoxifen; NDDtam = N-desdimethyltamoxifen; TamNox = tamoxifen-N-oxide.