Skip to main content

Table 4 Correlations between tamoxifen metabolite concentrations in tumor tissue and serum.

From: Steroid receptor coactivators, HER-2 and HER-3 expression is stimulated by tamoxifen treatment in DMBA-induced breast cancer

   Tam 4OHtam 4OHNDtam NDtam NDDtam TamNox
   Tumor Serum Tumor Serum Tumor Serum Tumor Serum Tumor Serum Tumor Serum
Tam              
Tumor r -            
  n -            
Serum r 0.70 -           
  n 5 -           
4OHtam             
Tumor r 1.00** 0.70 -          
  n 5 5 -          
Serum r −0.70 −0.19 −0.70 -         
  n 5 8 5 -         
4OHNDtam             
Tumor r 1.00** 0.70 1.00** −0.70 -        
  n 5 5 5 5 -        
Serum r −0.60 0.41 −0.60 −0.31 −0.60 -       
  n 5 8 5 8 5 -       
NDtam              
Tumor r 1.00** 0.70 1.00** −0.70 1.00** −0.60 -      
  n 5 5 5 5 5 5 -      
Serum r −0.70 0.14 −0.70 0.00 −0.70 0.91** −0.70 -     
  n 5 8 5 8 5 8 5 -     
NDDtam              
Tumor r 0.40 0.60 0.40 −0.10 0.40 −0.20 0.40 −0.60 -    
  n 5 5 5 5 5 5 5 5 -    
Serum r −0.50 −0.12 −0.50 −0.24 −0.50 −0.52 −0.50 −0.48 0.40 -   
  n 5 8 5 8 5 8 5 8 5 -   
TamNox              
Tumor r 0.80 0.50 0.80 −0.50 0.80 −0.60 0.80 −0.50 −0.10 −0.70 -  
  n 5 5 5 5 5 5 5 5 5 5 -  
Serum r 0.90* 0.41 0.90* 0.24 0.90* 0.43 0.90* 0.55 0.30 −0.21 0.90* -
  n 5 8 5 8 5 8 5 8 5 8 5 -
  1. Spearman’s nonparametric test. Correlation coefficients (r) are presented in the table.
  2. Significant correlations are indicated by italics and * = P < 0.05 or ** = P < 0.01.
  3. Tam = tamoxifen; 4OHtam = 4-hydroxytamoxifen; 4OHNDtam = 4-hydroxy-N-desmethyltamoxifen; NDtam = N-desmethyltamoxifen; NDDtam = N-desdimethyltamoxifen; TamNox = tamoxifen-N-oxide.