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Table 3 Tamoxifen and metabolites in serum and tumor tissue during oral tamoxifen treatment

From: Steroid receptor coactivators, HER-2 and HER-3 expression is stimulated by tamoxifen treatment in DMBA-induced breast cancer

  Serum# Tumor* Ratio
(n = 8) (n = 5) (n = 5)
Median (q1-q3) Median (q1-q3) Median (q1-q3)
Tam 203 (184-229) 11750 (7000-15475) 50 (36-74)
4OHtam 372 (319-499) 18850 (8625-25775) 36 (23-72)
4OHNDtam 552 (427-593) 48850 (26550-76750) 92 (45-136)
NDtam 371 (335-417) 33200 (18225-49825) 93 (46-136)
NDDtam 4.7 (4.4-6.5) 376 (152-688) 84 (36-164)
TamNox 159 (127-180) 49 (29-685) 0.3 (0.2-3.9)
4OHtam/tam 1.9 (1.7-2.2) 1.5 (1.2-1.7) -
NDtam/tam 1.7 (1.5-2.0) 2.8 (2.5-3.2) -
NDDtam/tam 0.02 (0.02-0.04) 0.04 (0.02-0.05) -
  1. # Tamoxifen and metabolite measurements are presented as ng/ml serum.
  2. *Tamoxifen and metabolite measurements are presented as ng/g tumor tissue.
  3. Tumor/serum ratios of concentrations of tamoxifen and metabolites.
  4. Concentration ratios of metabolite/tamoxifen.
  5. Tam = tamoxifen; 4OHtam = 4-hydroxytamoxifen; 4OHNDtam = 4-hydroxy-N-desmethyltamoxifen; NDtam = N-desmethyltamoxifen; NDDtam = N-desdimethyltamoxifen; TamNox = tamoxifen-N-oxide; q1-q3 = quartile 1 – quartile 3