Table 3 Tamoxifen and metabolites in serum and tumor tissue during oral tamoxifen treatment
|  | Serum# | Tumor* | Ratio‡ |
|---|---|---|---|
(n = 8) | (n = 5) | (n = 5) | |
Median (q1-q3) | Median (q1-q3) | Median (q1-q3) | |
Tam | 203 (184-229) | 11750 (7000-15475) | 50 (36-74) |
4OHtam | 372 (319-499) | 18850 (8625-25775) | 36 (23-72) |
4OHNDtam | 552 (427-593) | 48850 (26550-76750) | 92 (45-136) |
NDtam | 371 (335-417) | 33200 (18225-49825) | 93 (46-136) |
NDDtam | 4.7 (4.4-6.5) | 376 (152-688) | 84 (36-164) |
TamNox | 159 (127-180) | 49 (29-685) | 0.3 (0.2-3.9) |
4OHtam/tam †| 1.9 (1.7-2.2) | 1.5 (1.2-1.7) | - |
NDtam/tam †| 1.7 (1.5-2.0) | 2.8 (2.5-3.2) | - |
NDDtam/tam †| 0.02 (0.02-0.04) | 0.04 (0.02-0.05) | - |