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Table 3 Multivariable Survival Analysis Results by median methylation level (< median is the reference group)

From: Methylation of HIN-1, RASSF1A, RIL and CDH13 in breast cancer is associated with clinical characteristics, but only RASSF1A methylation is associated with outcome

Gene

Outcome

HR (95% CI)

p-value*

RIL

TTFR

1.53 (0.85, 2.77)

0.16

 

OS

1.12 (0.76, 1.67)

0.57

HIN-1

TTFR

1.49 (0.83, 2.68)

0.19

 

OS

1.21 (0.82, 1.80)

0.34

RASSF1A

TTFR

1.93 (1.02, 3.67)

0.045

 

OS

1.74 (1.11, 2.74)

0.016

CDH13

TTFR

0.75 (0.42, 1.33)

0.32

 

OS

1.15 (0.77, 1.70)

0.50

  1. The models include age (continuous), tumor size (continuous), S-phase, ER (continuous) and PR (continuous).
  2. *P-value from Cox regression model.
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BMC Cancer

ISSN: 1471-2407

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