Figure 1
From: Li-Fraumeni-like syndrome associated with a large BRCA1 intragenic deletion
Mapping of the intragenic BRCA1 deletion detected in a patient with multiple primary tumors and a cancer family history fulfilling criteria for TP53 and BRCA testing. In the upper panel, the array-CGH profile of a region at chromosome band 17q21.31, showing a heterozygous loss in copy number (red bar) of a genomic segment (image adapted from the Genomic Workbench software, Agilent Technologies). The lower panel displays the deleted segment (solid black bar) in the context of the genomic region, encompassing exons 9–19 of the BRCA1 gene according to the analysis of breakpoint sequencing data (image adapted from UCSC Genome Bioinformatics, http://genome.ucsc.edu, Build 37.1).