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Table 1 Chromosome imbalance regions in lung cancer (alteration frequency > 50%)

From: The database of chromosome imbalance regions and genes resided in lung cancer from Asian and Caucasian identified by array-comparative genomic hybridization

Chromosome

Cytobanda

Start siteb

End siteb

Size (Mb)c

BAC number

Alteration frequency (n=40)

Gene numberd

A. Asian

3

p13-14.1*

64934270

73536726

8.60

74

Gain: 73%

23

6

p22.1*

26562439

28452189

1.89

60

Gain: 70%

31

9

q21.13*

73445866

76242707

2.80

29

Gain: 70%

8

10

q21.3

69354590

71006065

1.65

15

Gain: 55%

23

10

q24.1

95664566

99431796

3.77

37

Gain: 58%

44

12

p13.31-13.32

2363194

8268165

5.90

44

Gain: 60%

58

13

q14.1-14.2*

42340030

47097431

4.76

38

Gain: 80%

22

17

p13.3*

373082

2754327

2.38

20

Gain: 60%

37

2

p23.2-23.3

25035233

33995335

8.96

75

Loss: 63%

83

2

p24.1

21212355

23783250

2.57

18

Loss: 58%

1

2

q35

215083214

215870969

0.79

9

Loss: 58%

5

3

p21.3-22.3*

33902686

44181635

10.28

82

Loss: 65%

90

4

p15.2-15.31

22255381

24549727

2.29

24

Loss: 60%

5

6

p22.2

23982002

25939112

1.96

68

Loss: 80%

16

12

q15

67646357

69188647

1.54

11

Loss: 55%

11

13

q13.3*

35856763

39003721

3.15

27

Loss: 65%

18

X

p22.31

5701499

5872842

0.17

2

Loss: 50%

1

Overall

      

476

B. Caucasian

2

p24.1-24.3

12723105

21045423

8.32

58

Gain: 55%

21

2

q25.1

11704089

12544967

0.84

7

Gain: 50%

2

3

p12.3-13*

67690502

79574641

11.88

96

Gain: 70%

22

3

p14.1-14.3*

56804094

67550231

10.75

65

Gain: 50%

26

3

p21.31-22.1

42559388

46459596

3.90

33

Gain: 60%

57

3

p25.3-26.3

1711179

9591700

7.88

72

Gain: 55%

20

6

p22.1-22.3*

20951128

28567815

7.62

132

Gain: 60%

97

9

q21.13*

75834015

76513536

0.68

6

Gain: 70%

5

13

q14.1-14.2*

40944092

47097431

6.15

47

Gain: 80%

24

17

p13.2-13.3*

481074

4001084

3.52

13

Gain: 70%

35

X

p22.11-22.2

16180300

22691476

6.51

49

Gain: 60%

26

2

p22.3

32854381

33890229

1.04

6

Loss: 50%

3

2

p24.3-25.1

31026798

31813698

0.79

6

Loss: 50%

3

3

p11.1-12.1

84572959

90247330

5.67

46

Loss: 70%

9

3

p22.2-22.3*

32980614

36795763

3.82

13

Loss: 75%

14

3

p23

31259835

32891762

1.63

13

Loss: 60%

10

6

p21.2-22.1

29049491

39602226

10.55

86

Loss: 70%

27

10

p23.1-23.2

82106537

89500949

7.39

79

Loss: 60%

36

12

p12.31

8090287

9190860

1.10

7

Loss: 50%

18

13

q13.3*

35856763

36315193

0.46

5

Loss: 80%

4

Overall

      

459

  1. a The common alteration regions in both Asian and Caucasian are marked with asterisk (*).
  2. b The information of cytoband start site and end site nucleotide sequences were from UCSC database (http://genome.ucsc.edu/, build 36 - hg18).
  3. c The sizes of cytoband were calculated from the start site to the end site nucleotide sequences.
  4. d The gene number of candidate genes was estimated by “NimbleGen: Transcription_Start_Sites.gff” annotation file (Roche, Palo Alto, CA). The annotation file indicates all transcription initiation sites for build hg18 as reported in the UCSC Genome browser.