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Figure 3 | BMC Cancer

Figure 3

From: The heat shock protein-90 co-chaperone, Cyclophilin 40, promotes ALK-positive, anaplastic large cell lymphoma viability and its expression is regulated by the NPM-ALK oncoprotein

Figure 3

NPM-ALK promotes Cyp40 and FKBP52, but not FKBP51, expression in ALK+ ALCL. Western blot analysis (left) and quantification (right) of Cyp40 (A), FKBP52 (B), and FKBP51 (C) protein levels in Karpas 299 and SUP-M2 cells transfected with pooled control or ALK siRNA. qRT-PCR analysis of Cyp40 (D) and FKBP52 (E) mRNA expression in Karpas 299 and SUP-M2 cells transfected with pooled control or ALK siRNA. Error bars represent the standard deviation of the mean of three independent experiments. p values were obtained using paired, one-tailed t-tests. N.S. indicates a p value >0.05.

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BMC Cancer

ISSN: 1471-2407

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