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Figure 2 | BMC Cancer

Figure 2

From: Experimental in vivo and in vitro treatment with a new histone deacetylase inhibitor belinostat inhibits the growth of pancreatic cancer

Figure 2

Apoptosis and necrosis in PDAC cell lines after treatment with belinostat and (or) gemcitabine. The percentage of dying tumour cells after treatment with belinostat, gemcitabine or belinostat + gemcitabine, stratified into early apoptotic, late apoptotic and necrotic fractions in the different PDAC cell lines. Belinostat increased apoptosis in a dose-dependent fashion in T3M4, AsPC-1 and Panc-1 cell lines. Moreover, the combination of belinostat and gemcitabine significantly enhanced apoptosis in T3M4 and Panc-1. Data are presented as mean ± SEM. * p < 0.05 vs. control

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