Figure 2From: Experimental in vivo and in vitro treatment with a new histone deacetylase inhibitor belinostat inhibits the growth of pancreatic cancer Apoptosis and necrosis in PDAC cell lines after treatment with belinostat and (or) gemcitabine. The percentage of dying tumour cells after treatment with belinostat, gemcitabine or belinostat + gemcitabine, stratified into early apoptotic, late apoptotic and necrotic fractions in the different PDAC cell lines. Belinostat increased apoptosis in a dose-dependent fashion in T3M4, AsPC-1 and Panc-1 cell lines. Moreover, the combination of belinostat and gemcitabine significantly enhanced apoptosis in T3M4 and Panc-1. Data are presented as mean ± SEM. * p < 0.05 vs. controlBack to article page