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Table 2 Tumor characteristics of evaluable patients

From: Biological characterization and selection criteria of adjuvant chemotherapy for early breast cancer: experience from the Italian observational NEMESI study

Disease characteristic (n = 1894)

Total, n (%)

CT, n (%)

No CT, n (%)

Tumor dimensions (pT)

· pT1mic-pT1a-pT1b

422 (22.3%)

132 (31.3%)

290 (68.7%)

· pT1c

846 (44.7%)

515 (60.9%)

331 (39.1%)

· pT2-pT3-pT4b

626 (33.0%)

448 (71.6%)

178 (28.4%)

Axillary lymph node status (pN)

· pN0

1155 (61.0%)

502 (43.5%)

653 (56.5%)

· pN1

551 (29.1%)

422 (76.6%)

129 (23.4%)

· pN2

119 (6.3%)

106 (89.1%)

13 (10.9%)

· pN3

69 (3.6%)

65 (94.2%)

4 (5.8%)

Estrogen and Progesterone Receptor (ER/PgR)

· ER or PgR-positive (≥1%)

1619 (85.5%)

829 (51.2%)

790 (48.8%)

· ER and PgR 0%

274 (14.5%)

266 (97.1%)

8 (2.9%)

· Unknown

1 (0.1%)

0 (0.0%)

1 (100%)

Proliferative index (Ki67 or MIB-1)

· Low (≤20%)

1150 (60.7%)

499 (43.4%)

651 (56.6%)

· High (>20%)

691 (36.5%)

562 (81.3%)

129 (18.7%)

· Unknown

53 (2.8%)

34 (64.2%)

19 (35.8%)

HER2

· Positive

305 (16.1%)

269 (88.2%)

36 (11.8%)

· Negative

1463 (77.2%)

761 (52.0%)

702 (48.0%)

· Unknown

126 (6.7%)

65 (51.6%)

61 (48.4%)

Biological type

· Luminal A

923 (48.7%)

352 (38.1%)

571 (61.9%)

· Luminal B

342 (18.1%)

230 (67.3%)

112 (32.7%)

· HER2

305 (16.1%)

269 (88.2%)

36 (11.8%)

· Triple negative

165 (8.7%)

161 (97.6%)

4 (2.4%)

· Unknown

159 (8.4%)

83 (52.2%)

76 (47.8%)

  1. Luminal A: ER or PgR ≥1% and proliferative index ≤20% and HER2-negative.
  2. Luminal B: ER or PgR ≥1% and proliferative index >20% and HER2-negative.
  3. HER2-positive: HER2-positive (IHC 3+, or IHC 2+ with HER2 amplified, HER2 amplified independently from IHC) independently from the values of ER, PgR, proliferative index.
  4. Triple negative: ER and PgR both 0% and HER2 negative independently from the proliferative index.