Figure 2

Immunohistochemical detection of VDR in HL. Exemplary cases of HL and B-NHL with expression of VDR are shown at low (10x) and high (40x, insert) magnification. The HL entities nodular sclerosing subtype (a), mixed cellularity subtype (b) and nodular lymphocyte predominant Hodgkin Lymphoma (c) are shown. Of B-NHL, samples of diffuse large B-cell lymphoma (d), follicular lymphoma (e), B-cell chronic lymphatic leukemia (f), marginal zone lymphoma (g) and Burkitt´s lymphoma (h) cases with staining reactions scored as positive are shown. In nodular sclerosing subtype of HL (A), also staining of activated T-cells and macrophages can be seen in the non neoplastic cellular background. Also in follicular lymphoma (E) macrophages staining strongly positive can be seen besides the tumor cells. B-NHL showed mostly cytoplasmatic positivity. Nuclear staining was found only in few cells of rare cases.