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Table 2 Packing density (expressed as the percentage of total area occupied by cell nuclei) and interstital fluid pressure (IFP) in tumour xenografts and the effect of treatment with bortezomib

From: Penetration of anticancer drugs through tumour tissue as a function of cellular packing density and interstitial fluid pressure and its modification by bortezomib

Bortezomib Treatment Time and Dose HCT-8Ea xenografts HCT-8E11 xenografts
Packing Density IFP Packing Density IFP
No Treatment 68.3 ± 2.4 9.5 ± 1.4 66.2 ± 1.9 10.0 ± 3.5
24 h after 0.5 mg/kg 68.8 ± 1.7 9.2 ± 3.7 64.5 ± 4.7 7.1 ± 2.1
24 h after 1.0 mg/kg 68.8 ± 3.4 7.3 ± 1.1 65.3 ± 3.3 7.1 ± 3.2
72 h after 0.5 mg/kg 68.2 ± 2.1 8.8 ± 2.5 66.3 ± 2.8 5.8 ± 2.4
72 h after 1.0 mg/kg 67.8 ± 2.9 6.6 ± 2.3 62.1 ± 4.8 5.1 ± 1.8*
  1. Data indicate mean +/- standard deviation for 7-9 animals per treatment group.
  2. * p≤0.05 for comparison with control conditions.