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Table 2 Packing density (expressed as the percentage of total area occupied by cell nuclei) and interstital fluid pressure (IFP) in tumour xenografts and the effect of treatment with bortezomib

From: Penetration of anticancer drugs through tumour tissue as a function of cellular packing density and interstitial fluid pressure and its modification by bortezomib

Bortezomib Treatment Time and Dose

HCT-8Ea xenografts

HCT-8E11 xenografts

Packing Density

IFP

Packing Density

IFP

No Treatment

68.3 ± 2.4

9.5 ± 1.4

66.2 ± 1.9

10.0 ± 3.5

24 h after 0.5 mg/kg

68.8 ± 1.7

9.2 ± 3.7

64.5 ± 4.7

7.1 ± 2.1

24 h after 1.0 mg/kg

68.8 ± 3.4

7.3 ± 1.1

65.3 ± 3.3

7.1 ± 3.2

72 h after 0.5 mg/kg

68.2 ± 2.1

8.8 ± 2.5

66.3 ± 2.8

5.8 ± 2.4

72 h after 1.0 mg/kg

67.8 ± 2.9

6.6 ± 2.3

62.1 ± 4.8

5.1 ± 1.8*

  1. Data indicate mean +/- standard deviation for 7-9 animals per treatment group.
  2. * p≤0.05 for comparison with control conditions.