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Table 1 Change in packing density of MCC (mean +/– standard deviation) at 24 h after exposure to varying concentrations of bortezomib

From: Penetration of anticancer drugs through tumour tissue as a function of cellular packing density and interstitial fluid pressure and its modification by bortezomib

Bortezomib concentration (μM)

MCC Packing Density (% nuclear area)

 

HCT-8Ea

HCT-8E11

0

53.2 ± 5.5

50.8 ± 3.8

0.25

50.9 ± 6.2

48.6 ± 3.2

0.50

50.2 ± 5.6

46.6 ± 4.1

1.0

44.6 ± 5.7*

42.5 ± 3.8*

2.5

45.9 ± 5.6*

MCC disaggregated

  1. MCC derived from both cell lines disaggregate when treated with 5 μM of bortezomib. Packing density changes were shown to be significant after pre-treatment with 1 μM of bortezomib (p = 1.3 × 10-7 and p = 1.8 × 10-6 for HCT-8Ea and HCT-8E11 derived MCC respectively as assessed using a t-test).
  2. * p≤0.05 for comparison with control conditions.
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BMC Cancer

ISSN: 1471-2407

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