Table 2 Follicular Lymphoma International Prognostic Index (FLIPI) and Follicular Lymphoma International Prognostic Index 2 (FLIPI 2)
FLIPI | ||||
|---|---|---|---|---|
Risk factors | ||||
· Age <60 years vs. ≥60 years | ||||
· Hemoglobin ≥12 g/dL vs. <12 g/dL | ||||
· Serum LDH ≤ ULN vs. >ULN* | ||||
· Ann Arbor stage I-II vs. III-IV | ||||
· No. of nodal sites ≤4 vs. >4 | ||||
Risk group | No. of factors | 5–year OS** | 10–year OS** | Relative risk |
Good | 0–1 | 91% | 71% | 1 |
Intermediate | 2 | 78% | 51% | 2.3 |
Poor | ≥3 | 53% | 36% | 4.3 |
FLIPI 2 | ||||
Risk factors | ||||
· Beta-2-microglobulin > ULN* | ||||
· Longest diameter of the largest involved node > 6 cm | ||||
· Bone marrow involvement | ||||
· Hemoglobin level < 12 gr/L | ||||
· Age older than 60 years | ||||
Risk group | No. of factors | 3-year PFS*** | 5-year PFS*** | Relative risk |
Low | 0 | 90.9% | 79.5% | 1 |
Intermediate | 1-2 | 69.3% | 51.2% | 3.19 |
High | 3-5 | 51.3% | 18.8% | 5.76 |