Table 3 Genes linked to genomic instability
From: Effects on human transcriptome of mutated BRCA1 BRCT domain: A microarray study
Biological Process | Gene Symbol | Gene Name | Contrast | log2 (Fold Change) |
|---|---|---|---|---|
DNA damage response and repair downregulation | EEF1E1 | eukaryotic translation elongation factor 1 epsilon 1 | A1789TvsWT | −0.4309041 |
|  | SMC1A | structural maintenance of chromosomes 1A | A1789TvsWT MutvsWT | −0.2754507 −0.2640263 |
|  | PPP1CC | protein phosphatase 1, catalytic subunit, gamma isozyme | A1789TvsWT | −0.4286825 |
|  | AHNAK | AHNAK nucleoprotein | A1789TvsWT M1775RvsWT MutvsWT | −0.3988113 |
|  |  |  |  | −0.3103867 |
|  |  |  |  | −0.3940570 |
|  | SOD2 | superoxide dismutase 2, mitochondrial | M1775RvsWT MutvsWT | −0.3376169 |
|  |  |  |  | −0.2502831 |
DNA damage response and repair upregulation | MRE11A | MRE11 meiotic recombination 11 homolog A (S. cerevisiae) | A1789TvsWT | 0.3293561 |
| Â | TERF1 | telomeric repeat binding factor (NIMA-interacting) 1 | MutvsWT | 0.2790907 |
| Â | OBFC2A | oligonucleotide/oligosaccharide-binding fold containing 2A | M1775RvsWT | 0.3666172 |
| Â | OBFC2B | oligonucleotide/oligosaccharide-binding fold containing 2B | A1789TvsWT MutvsWT | 0.4070777 |
| Â | Â | Â | Â | 0.3417360 |