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Table 2 Genes linked to aberrant cell proliferation

From: Effects on human transcriptome of mutated BRCA1 BRCT domain: A microarray study

Biological Process

Gene Symbol

Gene Name

Contrast

log2 (Fold Change)

Cell cycle arrest impairment

CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

M1775RvsWT

−0.3066647

 

CEBPA

CCAAT/enhancer binding protein (C/EBP), alpha

M1775RvsWT

MutvsWT

−0.3728651

    

−0.3190284

 

SMAD3

SMAD family member 3

A1789TvsWT

M1775RvsWT

MutvsWT

−0.2675322

    

−0.4286813

    

−0.3196246

 

CCND1

cyclin D1

A1789TvsWT

0.3622112

 

PML

promyelocytic leukemia

M1775RvsWT

−0.3045759

 

RUVBL1

RuvB-like 1 (E. coli)

M1775RvsWT

−0.3028029

 

TXNIP

thioredoxin interacting protein

A1789TvsWT

−0.3985633

 

RASSF1

Ras association (RalGDS/AF-6) domain family member 1

A1789TvsWT

−0.2766158

Cell proliferation enhancement

FOS

FBJ murine osteosarcoma viral oncogene homolog

A1789TvsWT

M1775RvsWT

MutvsWT

0.4515777

    

0.4020256

    

0.4365775

 

DUSP1

dual specificity phosphatase 1

A1789TvsWT

M1775RvsWT

MutvsWT

0.3844494

    

0.7606655

    

0.5060076

 

DUSP2

dual specificity phosphatase 2

MutvsWT

0.5408689

 

EDN1

endothelin 1

M1775RvsWT

MutvsWT

0.4442705

    

0.3212824

 

SKP1

S-phase kinase-associated protein 1

A1789TvsWT

0.3353208

 

ZWILCH

Zwilch, kinetochore associated, homolog (Drosophila)

A1789TvsWT

0.2508541

 

GPR56

G protein-coupled receptor 56

A1789TvsWT

M1775RvsWT

MutvsWT

−0.3453577

    

−0.3310188

    

−0.3407359

Apoptosis blocking

NFKB 1

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

M1775RvsWT

−0.2522979

 

TNFRSF10B

tumor necrosis factor receptor superfamily, member 10b

M1775RvsWT

−0.247568

 

DYRK2

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2

M1775RvsWT

−0.282513

 

PLEKHF1

pleckstrin homology domain containing, family F (with FYVE domain) member 1

MutvsWT

−0.2374774