From: Effects on human transcriptome of mutated BRCA1 BRCT domain: A microarray study
Biological Process | Gene Symbol | Gene Name | Contrast | log2 (Fold Change) |
---|---|---|---|---|
Cell cycle arrest impairment | CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | M1775RvsWT | −0.3066647 |
 | CEBPA | CCAAT/enhancer binding protein (C/EBP), alpha | M1775RvsWT MutvsWT | −0.3728651 |
 |  |  |  | −0.3190284 |
 | SMAD3 | SMAD family member 3 | A1789TvsWT M1775RvsWT MutvsWT | −0.2675322 |
 |  |  |  | −0.4286813 |
 |  |  |  | −0.3196246 |
 | CCND1 | cyclin D1 | A1789TvsWT | 0.3622112 |
 | PML | promyelocytic leukemia | M1775RvsWT | −0.3045759 |
 | RUVBL1 | RuvB-like 1 (E. coli) | M1775RvsWT | −0.3028029 |
 | TXNIP | thioredoxin interacting protein | A1789TvsWT | −0.3985633 |
 | RASSF1 | Ras association (RalGDS/AF-6) domain family member 1 | A1789TvsWT | −0.2766158 |
Cell proliferation enhancement | FOS | FBJ murine osteosarcoma viral oncogene homolog | A1789TvsWT M1775RvsWT MutvsWT | 0.4515777 |
 |  |  |  | 0.4020256 |
 |  |  |  | 0.4365775 |
 | DUSP1 | dual specificity phosphatase 1 | A1789TvsWT M1775RvsWT MutvsWT | 0.3844494 |
 |  |  |  | 0.7606655 |
 |  |  |  | 0.5060076 |
 | DUSP2 | dual specificity phosphatase 2 | MutvsWT | 0.5408689 |
 | EDN1 | endothelin 1 | M1775RvsWT MutvsWT | 0.4442705 |
 |  |  |  | 0.3212824 |
 | SKP1 | S-phase kinase-associated protein 1 | A1789TvsWT | 0.3353208 |
 | ZWILCH | Zwilch, kinetochore associated, homolog (Drosophila) | A1789TvsWT | 0.2508541 |
 | GPR56 | G protein-coupled receptor 56 | A1789TvsWT M1775RvsWT MutvsWT | −0.3453577 |
 |  |  |  | −0.3310188 |
 |  |  |  | −0.3407359 |
Apoptosis blocking | NFKB 1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | M1775RvsWT | −0.2522979 |
 | TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | M1775RvsWT | −0.247568 |
 | DYRK2 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 | M1775RvsWT | −0.282513 |
 | PLEKHF1 | pleckstrin homology domain containing, family F (with FYVE domain) member 1 | MutvsWT | −0.2374774 |