Skip to main content

Advertisement

Table 2 Genes linked to aberrant cell proliferation

From: Effects on human transcriptome of mutated BRCA1 BRCT domain: A microarray study

Biological Process Gene Symbol Gene Name Contrast log2 (Fold Change)
Cell cycle arrest impairment CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) M1775RvsWT −0.3066647
  CEBPA CCAAT/enhancer binding protein (C/EBP), alpha M1775RvsWT MutvsWT −0.3728651
     −0.3190284
  SMAD3 SMAD family member 3 A1789TvsWT M1775RvsWT MutvsWT −0.2675322
     −0.4286813
     −0.3196246
  CCND1 cyclin D1 A1789TvsWT 0.3622112
  PML promyelocytic leukemia M1775RvsWT −0.3045759
  RUVBL1 RuvB-like 1 (E. coli) M1775RvsWT −0.3028029
  TXNIP thioredoxin interacting protein A1789TvsWT −0.3985633
  RASSF1 Ras association (RalGDS/AF-6) domain family member 1 A1789TvsWT −0.2766158
Cell proliferation enhancement FOS FBJ murine osteosarcoma viral oncogene homolog A1789TvsWT M1775RvsWT MutvsWT 0.4515777
     0.4020256
     0.4365775
  DUSP1 dual specificity phosphatase 1 A1789TvsWT M1775RvsWT MutvsWT 0.3844494
     0.7606655
     0.5060076
  DUSP2 dual specificity phosphatase 2 MutvsWT 0.5408689
  EDN1 endothelin 1 M1775RvsWT MutvsWT 0.4442705
     0.3212824
  SKP1 S-phase kinase-associated protein 1 A1789TvsWT 0.3353208
  ZWILCH Zwilch, kinetochore associated, homolog (Drosophila) A1789TvsWT 0.2508541
  GPR56 G protein-coupled receptor 56 A1789TvsWT M1775RvsWT MutvsWT −0.3453577
     −0.3310188
     −0.3407359
Apoptosis blocking NFKB 1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 M1775RvsWT −0.2522979
  TNFRSF10B tumor necrosis factor receptor superfamily, member 10b M1775RvsWT −0.247568
  DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 M1775RvsWT −0.282513
  PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1 MutvsWT −0.2374774