TY - JOUR AU - Iofrida, Caterina AU - Melissari, Erika AU - Mariotti, Veronica AU - Guglielmi, Chiara AU - Guidugli, Lucia AU - Caligo, Maria Adelaide AU - Pellegrini, Silvia PY - 2012 DA - 2012/05/30 TI - Effects on human transcriptome of mutated BRCA1 BRCT domain: A microarray study JO - BMC Cancer SP - 207 VL - 12 IS - 1 AB - BRCA1 (breast cancer 1, early onset) missense mutations have been detected in familial breast and ovarian cancers, but the role of these variants in cancer predisposition is often difficult to ascertain. In this work, the molecular mechanisms affected in human cells by two BRCA1 missense variants, M1775R and A1789T, both located in the second BRCT (BRCA1 C Terminus) domain, have been investigated. Both these variants were isolated from familial breast cancer patients and the study of their effect on yeast cell transcriptome has previously provided interesting clues to their possible role in the pathogenesis of breast cancer. SN - 1471-2407 UR - https://doi.org/10.1186/1471-2407-12-207 DO - 10.1186/1471-2407-12-207 ID - Iofrida2012 ER -