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Table 1 Top 20 up and downregulated genes in p80HT B cells

From: NF-κB2 mutation targets survival, proliferation and differentiation pathways in the pathogenesis of plasma cell tumors

Gene

RefSeq

Fold

P value

Gene ontology/biological function

Penk

NM_001002927

5.77

0.00098

Neuropeptide signaling pathway

Hbb-b1

NM_008220

4.87

0.00662

Positive regulation of cell proliferation

IL-15

NM_008357

4.57

0.00112

Lymph node development

Lphn2

NM_001081298

4.06

0.00248

G-protein coupled receptor protein signaling pathway

IL-10

NM_010548

4.02

0.00715

Immune response/regulation of gene expression

Hba-a2

NM_001083955

3.95

0.00213

Oxygen transport

Hba-a1

NM_008218

3.74

0.00248

Oxygen transport

B4galt6

NM_019737

3.72

0.00044

Galactosyltransferase activity

Ehf

NM_007914

3.67

0.00004

Positive regulation of transcription, DNA-dependent

CD80

NM_009855

3.65

0.00156

Positive regulation of peptidyl-tyrosine phosphorylation

Dmxl2

NM_172771

3.61

0.00185

Rab GTPase binding

Ryk

NM_013649

3.24

0.00229

Wnt receptor signaling pathway

Pmepa1

NM_022995

3.21

0.00149

Protein binding

Mllt4

NM_010806

2.95

0.00013

Cell adhesion/signal transduction

Csf2rb

NM_007780

2.88

0.00081

Cytokine-mediated signaling pathway

Ikzf2

NM_011770

2.78

0.00628

Regulation of transcription

Nt5e

NM_011851

2.77

0.00001

AMP catabolic process

Plscr1

NM_011636

2.75

0.00348

Response to virus

Tnfsf8

NM_009403

2.68

0.00839

Immune response

Ccnd2

NM_009829

2.58

0.00868

Regulation of cell cycle

Vpreb3

NM_009514

-3.95

0.00584

Pre-B cell receptor (BCR) signals

Hes1

NM_008235

-3.78

0.00235

Negative regulation of transcription

Rapgef4

NM_019688

-3.58

0.00435

Regulation of protein amino acid phosphorylation

Zfp608

NM_175751

-3.55

0.00982

Zinc ion binding

Cecr2

NM_001128151

-3.19

0.00535

Apoptosis

Tmem108

NM_178638

-3.02

0.00574

Tramsmembrane protein

CD36

NM_001159557

-2.79

0.00040

Positive regulation of cell-matrix adhesion

D8Ertd82e

NM_172911

-2.55

0.00168

Protein amino acid phosphorylation

Treml2

NM_001033405

-2.47

0.00796

T cell activation

Slc6a16

XM_914689

-2.41

0.00426

Solute carrier

Hist3h2a

NM_178218

-2.40

0.00475

Nucleosome assembly

Satb1

NM_009122

-2.36

0.00289

Negative regulation of transcription

Rftn2

NM_028713

-2.33

0.00548

Raftlin Family

Gad1

NM_008077

-2.32

0.00184

Carboxylic acid metabolic process

Gdf11

NM_010272

-2.30

0.00225

Negative regulation of cell proliferation

Itgb3

NM_016780

-2.16

0.00482

Integrin-mediated signaling pathway

Acsf2

NM_153807

-2.13

0.00050

Fatty acid metabolic process

Zfp69

NM_001005788

-2.05

0.00718

Regulation of transcription, DNA-dependent

Pip5k1b

NM_008846

-2.05

0.00710

Phosphatidylinositol metabolic process

Smad7

NM_001042660

-2.03

0.00463

Negative regulation of transcription