Figure 4From: NF-κB2 mutation targets survival, proliferation and differentiation pathways in the pathogenesis of plasma cell tumors Stat3 inhibition induces growth arrest and cell death in human MM cell lines. (A) Immunoblot analysis of Stat3, pStat3-Y705, cyclin D1, cyclin D2 and survivin in human MM cell lines treated for 24 h with S3I-201 (RPMI-8226, 100 μM; H929 and EJM, 50 μM). β-actin levels are shown as loading control. (B-D) Quantification of cell growth and cell death of H929 (B), RPMI-8229 (C) and EJM (D) cells at various time points following treatment with S3I-201 at the indicated concentrations. Graphs are representative of two independent experiments.Back to article page