Normalized isobolograms depicting the pharmacological interaction of mifepristone (MF) when it follows cisplatin (CDDP) and/or paclitaxel (PTX) as calculated from the comparative dose response curves depicted in Figure 5
. (A) Interaction between CDDP and MF. (B) Interaction among PTX and MF. (C) Interaction between MF and the combination CDDP-PTX, which was considered as ‘one treatment’ for the calculation purposes. The normalized isobolograms were obtained using CalcuSyn software. The depicted combination indexes (CI) in the isobolograms (*) were calculated using the doses of 20 μM CDDP, 100 nM PTX and 10 μM MF; n = 3.